Cell-Surface Materials Interactions conducted at the Nanoscale Interface

The study of cell-surface interactions involves important physicochemical parameters for controlling biomaterials' cell bonding contact behaviors. Recently, the number of research topics and advanced studies have been growing explaining the formation of cell-to-surface materials contacts at the nanoscale level. Behind those relevant works, the different properties at the physicochemical level have suggested that they play a pivotal role in forming nanoscale interface interactions between bacterial, fungal, and even mammalian cells. Far more important are the resulting cellular fates from the nanoscale initial bonding interaction by the growing number of advanced materials. Therefore, cellular trends have been detected by the increasing formation of cellular contacts at the nanoscale; for example, increased cellular adhesion, promoted proliferation, and microbial colonization.

Interestingly, the viability of the cells increases due to the well-established cell-nanoscale interactions. On the other hand, the characterization of the formation of cell contact bonds at the nanoscale interface requires advanced techniques in order to reveal these interesting phenomena. Taking together the control of the design of intelligent surfaces and the advanced fabrication of the new generation of biomaterials, we can develop innovative coatings for directing the cell-surface materials interactions conducted at the nanoscale interfaces for biomedical and industrial applications.

The present Research Topic aims to establish a scientific forum to discuss the most recent advances and future research on the role of material surface physicochemical patterns in conducting cell-surface interactions at the nanoscale that direct different biochemical and molecular functions. Furthermore, to uncover the mechanisms behind the formation of cell bonds (bacteria, fungi, and tissue) on different materials from across polymers, ceramics, metals, and composites for biomedical and industrial applications.

This Research Topic is interested in publishing research articles, reviews, mini reviews, and perspectives focused on the role of surface materials in conducting cellular/nanomaterials interactions at the nanoscale and their subsequent cellular response. Research topics and areas to be covered may include, but are not limited to:

• Bacterial interactions at the nanoscale.

• Fungal interactions at the nanoscale.

• Mammalian cellular interactions at the nanoscale.

• Mechano-mediated cell behavior.

• Focal adhesions conducted by nanoscale interactions.

• Focus Ion Beam-FE-SEM studies centered on evaluating cell-nanoscale interactions.

• Cell-materials nanoscale interface bonding for control of cellular fate.

Keywords: Cell-nanoscale interactions, Mechano-cellular interactions, Cellular nano-adhesion bonds, Biomaterials, Cellular adhesion

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.