About this Research Topic
Malformations or dysfunctions of these mid-hindbrain derived neurons are associated with many human brain disorders. Many of those disorders are based on neurodevelopmental malformations, like ataxias, sensory-motor gating deficits and psychiatric disorders, the later including bipolar mood disorders, schizophrenia and addiction. The recent progress in neuroimaging and genetic technologies provided a deep insight into a wide spectrum of congenital disorder of mid- and hindbrain, which are largely caused by neurodevelopmental malformations. Thus, there is a renewed interest in understanding the mechanisms that regulate the development of these brain regions. Despite great advances in understanding normal and abnormal development of the mid-hindbrain area in mouse, chick and zebrafish, many unresolved issues remain that cloud our view of the assembly of these brain structures.
More knowledge about the mechanisms underlying the assembly of the mid-hindbrain will not only provide insights into basic patterning processes in brain development, but also help clinical understanding of neural disorders associated with these brain regions and potentially facilitate therapies for those disorders.
The Research Topic aims to highlight and cover the current understanding of the patterning of those regions in different animal models. Contributors are welcome to submit reviews, mini-reviews, commentaries, perspectives and original research articles.
Keywords: midbrain, mid-hindbrain boundary, cerebellum, neural development
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