BW
busen wang
Beijing Institute of Biotechnology
Beijing, China
About this Research Topic
This Research Topic is closed for submissions.
Background
The adaptive immune response elicited by vaccination or pre-infection is the most important defense line of the body against the invasion of the pathogenic virus. However, there are significant differences in the type, effect intensity, and duration of adaptive immune responses induced by different kinds of vaccines or natural infections. Understanding the immune response patterns is important for the determination of vaccination strategies. Especially for SARS-CoV-2, continued mutation of the virus challenges the body's immunity, and various forms of specific vaccines including inactivated virus vaccines, subunit vaccines, viral vector vaccines, and nucleic acid vaccines have been developed and approved for use. The difference and characteristic advantages of vaccines are hot topics worthy of discussion.
This Research Topic aims to figure out the characteristics of adaptive immune response induced by certain types of vaccines or natural infections to further understand the effective immune patterns against specific pathogenic viruses. Research topics can involve new approaches for constructing vaccines, such as novel viral vectors, novel vaccine adjuvants, novel packaging materials for nucleic acid delivery, a novel design of antigen proteins, etc., and their specific immune effects. The point of interest of the topic is more inclined to comparative studies of the adaptive immune response following vaccination or natural infection, or comparisons of the adaptive immune response elicited by different types of vaccine, or a comprehensive study on the broad-spectrum effect of vaccine, especially for SARS-CoV-2.
• Novel approaches for vaccine construction against pathogenic viruses, including:
novel viral vectors for antigen delivery,
novel packaging methods for nucleic acid delivery,
novel design of antigen proteins,
novel vaccine delivery routes and their immune effects, etc.
• Novel methods for detection of adaptive immune responses, including:
novel approaches for neutralizing antibody detection,
comprehensive designs for the detection of complex memory immune T/B cells,
convenient methods for the detection of respiratory mucosal immune responses in humans or non-human primates,
Ingenious animal model for vaccine effectiveness testing under routine laboratory conditions, etc.
• Comparative studies of adaptive immune responses, including:
comparative studies of immune responses between post-vaccination and post-infection,
comparison of responses elicited by different types of vaccines,
novel routes for vaccination, through mucosal or oral administration,
broad-spectrum of responses against different virus strains or variants of SARS-CoV-2, etc.
Keywords: adaptive immune response, vaccination, SARS-CoV-2
Important note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
