Endometrial thickness is associated with clinical outcomes in embryo implantation. A thin endometrium not only causes a lower implantation rate but also results in the rise to obstetric complications and adverse perinatal outcomes. However, the mechanism of how thin endometrium leads to poor endometrium receptivity is remained to be further explored.
Various methods have been used to improve the clinical outcome for patients with thin endometrium. The growth of endometrium is mainly controlled by hormones. An increasing dose of estrogen and an extension of duration may be helpful in improving the thickness of endometrium, but not always. Some growth factors, such as human granulocyte cell stimulating factor, the platelet growth factor, were proved effective in some studies. Furthermore, endometrium regeneration using stem cell therapy may be another promising method to address this problem. Nevertheless, none of these strategies have been proven to be “an ultimate solution” to thin endometrium.
This Research Topic aims at exploring the mechanisms of the poor endometrium receptivity of thin endometrium. Besides, it also focuses on various strategies to improve the clinical outcomes of patients with thin endometrium.
We welcome submissions of the following subtopics, but not limited to:
? The mechanisms of the poor endometrium receptivity of thin endometrium.
? Novel strategies to improve the clinical outcomes of thin endometrium.
? Hormone regulation in the growth and regeneration of endometrium.
Endometrial thickness is associated with clinical outcomes in embryo implantation. A thin endometrium not only causes a lower implantation rate but also results in the rise to obstetric complications and adverse perinatal outcomes. However, the mechanism of how thin endometrium leads to poor endometrium receptivity is remained to be further explored.
Various methods have been used to improve the clinical outcome for patients with thin endometrium. The growth of endometrium is mainly controlled by hormones. An increasing dose of estrogen and an extension of duration may be helpful in improving the thickness of endometrium, but not always. Some growth factors, such as human granulocyte cell stimulating factor, the platelet growth factor, were proved effective in some studies. Furthermore, endometrium regeneration using stem cell therapy may be another promising method to address this problem. Nevertheless, none of these strategies have been proven to be “an ultimate solution” to thin endometrium.
This Research Topic aims at exploring the mechanisms of the poor endometrium receptivity of thin endometrium. Besides, it also focuses on various strategies to improve the clinical outcomes of patients with thin endometrium.
We welcome submissions of the following subtopics, but not limited to:
? The mechanisms of the poor endometrium receptivity of thin endometrium.
? Novel strategies to improve the clinical outcomes of thin endometrium.
? Hormone regulation in the growth and regeneration of endometrium.