About this Research Topic
As the population ages, cancer has become a public health problem and is one of the most important causes of death worldwide. Cancer progression is a dynamic process in which tumor cells interact with the microenvironments, including anti-tumor immune cells, cytokines, immunosuppressive cells, and substances. This complex mechanism has caused difficulties in clinical treatment. Recent studies have shown that immunotherapy, represented by immune checkpoint inhibitors, can effectively inhibit tumor progression by regulating the immune microenvironment. However, its clinical application is limited by the small number of beneficiaries, side effects, and drug resistance. In the field of anti-cancer, some fragmented research suggested that natural products can exert anti-tumor activity by activating the immune system, amplifying effector cells, infiltrating the activated effector cells into tumor tissues, and destroying tumor cells and other immune reactions.
At present, many natural anti-cancer products, such as paclitaxel, vincristine, and colchicine, have been proven to have excellent anti-cancer effects and have been put into clinical practice. Natural products have been a valuable source of new drugs for clinical treatment because of their essential role in biological activities and the diversity of their metabolites. Unfortunately, there is still a lack of research on the role of natural anti-cancer products in the immune microenvironment.
This Research Topic focuses on the mechanisms of natural anti-cancer products regulating the immune microenvironment. Our goal is to complement and refine the important effects of natural anticancer products on the immune microenvironment, as well as to encourage the discovery and research of novel anticancer drugs and pave the way for the clinical application of new treatment strategies. The topics of interest include but are not limited to the following.
● The mechanism of anti-tumor components of natural products regulating the immune microenvironment
● Identification of potential therapeutic targets for precision treatment of cancer patients based on the regulation of the immune microenvironment by natural products
● Pharmacodynamic basis and molecular mechanism of antitumor components of natural products regulating immune microenvironment
● Novel antitumor clinical treatment strategies combining natural products with immunotherapy and/or chemotherapy
At present, many natural anti-cancer products, such as paclitaxel, vincristine, and colchicine, have been proven to have excellent anti-cancer effects and have been put into clinical practice. Natural products have been a valuable source of new drugs for clinical treatment because of their essential role in biological activities and the diversity of their metabolites. Unfortunately, there is still a lack of research on the role of natural anti-cancer products in the immune microenvironment.
This Research Topic focuses on the mechanisms of natural anti-cancer products regulating the immune microenvironment. Our goal is to complement and refine the important effects of natural anticancer products on the immune microenvironment, as well as to encourage the discovery and research of novel anticancer drugs and pave the way for the clinical application of new treatment strategies. The topics of interest include but are not limited to the following.
● The mechanism of anti-tumor components of natural products regulating the immune microenvironment
● Identification of potential therapeutic targets for precision treatment of cancer patients based on the regulation of the immune microenvironment by natural products
● Pharmacodynamic basis and molecular mechanism of antitumor components of natural products regulating immune microenvironment
● Novel antitumor clinical treatment strategies combining natural products with immunotherapy and/or chemotherapy
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