About this Research Topic
Extremozymes are enzymes derived from extremophilic microorganisms that are able to stay active and stable under various extreme conditions, which are considered destructive for mesophilic enzymes. These enzymes are able to withstand conditions such as extreme temperatures, high salt, high alkalinity or acidity. Some enzymes are tolerant to other extreme conditions including high pressure, and high levels of denaturants and solvents. Industrial processes are harsh and thus can denature or inactivate mesophilic enzymes. The need for extremozymes in the market has increased in the past decade owing to their use in multiple industrial applications. Currently, extremozymes have tremendous potential applications in agriculture, pharmaceutical, detergent, food, beverages, textiles, leather, pulp and paper, and biomining industries.
The goal of this Research Topic is to explore extremozymes with increased efficiency and novel features to identify their novel applications. Novel features are usually coupled with the structural configuration of enzymes. Structural elucidation of an enzyme using different techniques such as CD spectroscopy, FT-IR, NMR, and XRD helps to determine the structure-function relationship and possible adaptation mechanism in different extreme conditions. Structural insights will pave the way for enzyme engineering for suitable application. Novel extremozymes with new features can be obtained by exploring microbial diversity from a range of different extreme and unusual environments and thereby the discovery of novel microbes. Alternatively, a novel biocatalyst can be designed by altering the structure of the enzyme using a protein engineering approach to get desired traits.
This Research Topic welcomes Original Research articles, Reviews, Mini Reviews, and Methods emphasizing but not limited to the following themes:
● Screening and production of extremozymes with novel features from extreme habitats;
● Purification and characterization of the novel extremophilic enzymes with high activity and stability under extreme conditions and their potential applications;
● Structural insights into the adaptation mechanism of extremozymes;
● Designing novel extremophilic enzymes using the protein engineering approaches.
Articles focusing merely on screening and production without thorough enzyme characterization will be considered out of the scope.
This Research Topic was coordinated by Dr. Hitarth B. Bhatt, an Assistant Professor at the Department of Microbiology, Faculty of Science, Atmiya University, India. His current research interests include extremophiles and extremozymes, protein expression and purification, structure-function relationship of enzymes, discovery of novel microbes, and microbial diversity & phylogeny.
The goal of this Research Topic is to explore extremozymes with increased efficiency and novel features to identify their novel applications. Novel features are usually coupled with the structural configuration of enzymes. Structural elucidation of an enzyme using different techniques such as CD spectroscopy, FT-IR, NMR, and XRD helps to determine the structure-function relationship and possible adaptation mechanism in different extreme conditions. Structural insights will pave the way for enzyme engineering for suitable application. Novel extremozymes with new features can be obtained by exploring microbial diversity from a range of different extreme and unusual environments and thereby the discovery of novel microbes. Alternatively, a novel biocatalyst can be designed by altering the structure of the enzyme using a protein engineering approach to get desired traits.
This Research Topic welcomes Original Research articles, Reviews, Mini Reviews, and Methods emphasizing but not limited to the following themes:
● Screening and production of extremozymes with novel features from extreme habitats;
● Purification and characterization of the novel extremophilic enzymes with high activity and stability under extreme conditions and their potential applications;
● Structural insights into the adaptation mechanism of extremozymes;
● Designing novel extremophilic enzymes using the protein engineering approaches.
Articles focusing merely on screening and production without thorough enzyme characterization will be considered out of the scope.
This Research Topic was coordinated by Dr. Hitarth B. Bhatt, an Assistant Professor at the Department of Microbiology, Faculty of Science, Atmiya University, India. His current research interests include extremophiles and extremozymes, protein expression and purification, structure-function relationship of enzymes, discovery of novel microbes, and microbial diversity & phylogeny.
Keywords: Extremozymes, extremophilic enzymes, protein engineering, extremophiles, structure-function relationship, enzymes, extreme, conditions, temperature, high alkalinity, acidity, high pressure, agriculture, pharmaceutical, food, textiles, paper, biomining, spectroscopy, FT-IR, NMR, XRD
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
