Movement disorders and psychiatric disorders have been progressively impacting the world population. When medication no longer offers relief, the technology of neuromodulation such as deep brain stimulation (DBS) seems to be an ideal alternative, which has been commonly used for the treatment of movement ...
Movement disorders and psychiatric disorders have been progressively impacting the world population. When medication no longer offers relief, the technology of neuromodulation such as deep brain stimulation (DBS) seems to be an ideal alternative, which has been commonly used for the treatment of movement disorders such as Parkinson's disease (PD), and medication-resistant psychiatric disorders such as obsessive compulsive disorder (OCD). Using biomarkers closely correlated to specific motor and non-motor symptoms as input, the novel system can detect pathological signal changes in brain circuits and contain them with proper stimulation patterns. As the evolution of neuromodulation goes on, the trend of developing closed-loop neuromodulation technology is unstoppable. Identifying the biomarkers closed related to the motor (tremor, rigidity and dyskinesia etc.) and non-motor features (anxiety, depression and apathy etc.) in the related brain circuits is important to develop closed-loop neuromodulation systems in movement disorders and psychiatric disorders. As the modulated targets and brain networks for movement disorders and psychiatric disorders partially overlap and some patients have both physical and psychological disorders, it is valuable to discuss the biomarkers of neuromodulation in these diseases together.
This Research Topic aims to explore the up-to-date progress in biomarkers for closed-loop neurostimulation in movement disorders and psychiatric diseases. The scope of submissions includes but is not limited to:
- Clinical research on the therapeutic effect of neuromodulation on movement disorders and psychiatric diseases.
- Exploratory research on the relationship between biomarkers (local field potential, blood oxygenation level dependent, etc.) and DBS therapeutic efficacy on movement disorders and psychiatric diseases.
- DBS clinical therapeutic effect prediction and multi-site intervention models based on postoperative electrode reconstruction and brain network interaction.
- Single- or multi-site closed-loop neuromodulation evidence based on brain connectome (imaging, electrophysiology, etc.).
closed-loop neuromodulation, deep brain stimulation, movement disorders, psychiatric disorders, biomarkers
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