About this Research Topic
Heart failure poses a major public health threat worldwide. Despite care and therapy improvement for its treatment, morbidity and mortality remain high. However, advances in translational research are providing new insights into the underlying mechanisms of heart failure and offering promising strategies for myocardial repair. One of the most promising areas of translational research in heart failure and cardiac repair is stem cell therapy. Clinical trials have shown that stem cell therapy can improve cardiac function in patients with heart failure. Yet one of the challenges of stem cell therapy is to ensure that the transplanted cells will survive and integrate into the existing myocardium.
Another advancement of translational research in heart failure is the development of new therapies that target specific molecular pathways involved in the pathogenesis of the disease. In addition to pharmacological therapies, there is growing interest in non-pharmacological approaches to myocardial repair and heart failure management, such as device-based therapies to improve patients’ cardiac function and relieve symptoms. While there is still much to learn, these advances offer hope for improved outcomes for patients with this debilitating condition.
In this research topic, we will focus on basic and clinical translational studies on the molecular mechanism, pharmacological and therapeutic aspects of myocardial repair and heart failure. We encourage authors to submit original research, review, opinion, and perspective articles, including the following subtopics, but not limited to:
- Recent approaches to cardiac regeneration and tissue engineering, including stem cell therapy, gene therapy, and tissue engineering etc.
- Diagnostic and prognostic applications of circulating biomarkers that can identify patients at risk of heart failure and track the progression of the disease.
- Precision medicine to develop personalized treatments, including individual genetic makeup and lifestyle.
- New invented applicable medical devices that can help manage heart failure by regulating the heart's electrical activity and improving its pumping function.
Another advancement of translational research in heart failure is the development of new therapies that target specific molecular pathways involved in the pathogenesis of the disease. In addition to pharmacological therapies, there is growing interest in non-pharmacological approaches to myocardial repair and heart failure management, such as device-based therapies to improve patients’ cardiac function and relieve symptoms. While there is still much to learn, these advances offer hope for improved outcomes for patients with this debilitating condition.
In this research topic, we will focus on basic and clinical translational studies on the molecular mechanism, pharmacological and therapeutic aspects of myocardial repair and heart failure. We encourage authors to submit original research, review, opinion, and perspective articles, including the following subtopics, but not limited to:
- Recent approaches to cardiac regeneration and tissue engineering, including stem cell therapy, gene therapy, and tissue engineering etc.
- Diagnostic and prognostic applications of circulating biomarkers that can identify patients at risk of heart failure and track the progression of the disease.
- Precision medicine to develop personalized treatments, including individual genetic makeup and lifestyle.
- New invented applicable medical devices that can help manage heart failure by regulating the heart's electrical activity and improving its pumping function.
Keywords: heart failure, myocardial repair, translational insights, stem cell therapy, device-based therapies
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