About this Research Topic
Diabetic Cardiomyopathy (DBCM) is a serious complication of the myocardium of diabetic patients characterized by ventricular dilation and hypertrophy, diastolic dysfunction, decreased or preserved systolic function, and reduced ejection fraction in the absence of coronary artery disease or hypertension. The main symptom is extensive myocardium necrosis caused by metabolic disorders and microvascular lesions, which results in abnormal cardiac function and eventually progresses to heart failure, arrhythmia, and even sudden cardiac death, for which no specific treatment is currently available. DBCM is the leading cause of death in diabetic patients, especially those with type 2 diabetes. Ventricular remodeling caused by abnormal function and expression of various ion channels, exchangers, and ion pumps in the heart is the leading cause of calcium homeostasis imbalance in myocardial cells and cardiac insufficiency in DBCM patients. An in-depth understanding of the pathogenesis of DBCM (especially ventricular remodeling) and the treatment strategy that corresponds to this understanding will help to lay the theoretical groundwork for both early intervention in DBCM and the development of new treatment methods.
In this Research Topic, we would like to discuss the pathophysiological mechanisms of DBCM, with a particular emphasis on the involvement of ventricular remodeling due to electrophysiological alterations, microRNA, and calcium regulation abnormalities under DBCM, aiming to identify novel clinical markers for early diagnosis of DBCM and to develop novel therapeutic techniques to combat it.
This research topic considers manuscripts on all aspects of DBCM, including basic, translational, and clinical study. The broad topic is intended to cover all research related to, but not limited to, studies seeking to clarify the recent advances in understanding the progress research of DBCM, that include,
1) Role of ventricular remodeling (particularly electrophysiological changes) in the progression of DBCM.
2) Novel molecular factors and as potential therapeutic targets in DBCM.
3) Screening of clinical biomarkers in the early stage of DBCM.
4) Multi-omics approach in identifying new factors of DCM.
5) Novel cardiovascular imaging techniques for the early detection and risk stratification of patients with DBCM.
Original research, reviews, methods, brief research reports, commentaries, and opinions are all welcome in this Research Topic. Researchers working on diabetes and cardiovascular disease are strongly encouraged to submit their findings here.
In this Research Topic, we would like to discuss the pathophysiological mechanisms of DBCM, with a particular emphasis on the involvement of ventricular remodeling due to electrophysiological alterations, microRNA, and calcium regulation abnormalities under DBCM, aiming to identify novel clinical markers for early diagnosis of DBCM and to develop novel therapeutic techniques to combat it.
This research topic considers manuscripts on all aspects of DBCM, including basic, translational, and clinical study. The broad topic is intended to cover all research related to, but not limited to, studies seeking to clarify the recent advances in understanding the progress research of DBCM, that include,
1) Role of ventricular remodeling (particularly electrophysiological changes) in the progression of DBCM.
2) Novel molecular factors and as potential therapeutic targets in DBCM.
3) Screening of clinical biomarkers in the early stage of DBCM.
4) Multi-omics approach in identifying new factors of DCM.
5) Novel cardiovascular imaging techniques for the early detection and risk stratification of patients with DBCM.
Original research, reviews, methods, brief research reports, commentaries, and opinions are all welcome in this Research Topic. Researchers working on diabetes and cardiovascular disease are strongly encouraged to submit their findings here.
Keywords: diabetes, diabetic cardiomyopathy, cardiovascular disease, oxidative stress, calcium handling, ventricular remodeling
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
