The use of vaccines to prevent infectious diseases represents a tremendous accomplishment of biomedical science. However, there are still many unmet needs. How to achieve higher efficacy, longer memory T cell and B cell response, broader protection, local mucosal protection, and minimal side effects remain important challenges in the field.
Compared to the limited options for antigens and adjuvants, vaccine delivery systems appear to be highly diverse and play more complicated roles during vaccine immune responses. A vaccine delivery system is broadly defined here as anything that changes the spatial or temporal distribution of native antigens (of various forms, protein, DNA, mRNA, lipid, polysaccharide, etc.) or adjuvants. By this definition, vaccine delivery systems include but are not limited to chemical-based nanomaterials (such as liposome, emulsion, micelle, polymer, etc.), protein-based nanoparticles (such as virus-like particles, ferritin, etc.), and microbes in their native, attenuated, engineered, or inactivated forms. A deeper understanding of how the difference in the spatial or temporal distribution of antigens or adjuvants would influence the immune system at organ/tissue/cellular/subcellular levels and dynamically for specialized adaptive immune response induction and maintenance might provide novel insights for the rational design of better vaccines.
This Research Topic aims to provide a forum to stimulate critical and creative thinking and showcase advanced research on the immunological mechanisms of vaccine delivery systems. Subtopics include but are not limited to the following:
1) Novel designs targeting specific organs/tissues/cells/subcellular compartments
2) Mucosal vaccine delivery
3) Novel designs for temporal control of antigen/adjuvant delivery
4) The effect and mechanism of delivery systems on antigen processing and presentation
5) The effect and mechanism of delivery systems on adjuvant function
6) Novel stromal or immune cell subsets important for specialized T/B cell response, including long-term memory
7) Comparison of landscapes, at multiple levels, of the immune system upon different vaccine deliveries
The use of vaccines to prevent infectious diseases represents a tremendous accomplishment of biomedical science. However, there are still many unmet needs. How to achieve higher efficacy, longer memory T cell and B cell response, broader protection, local mucosal protection, and minimal side effects remain important challenges in the field.
Compared to the limited options for antigens and adjuvants, vaccine delivery systems appear to be highly diverse and play more complicated roles during vaccine immune responses. A vaccine delivery system is broadly defined here as anything that changes the spatial or temporal distribution of native antigens (of various forms, protein, DNA, mRNA, lipid, polysaccharide, etc.) or adjuvants. By this definition, vaccine delivery systems include but are not limited to chemical-based nanomaterials (such as liposome, emulsion, micelle, polymer, etc.), protein-based nanoparticles (such as virus-like particles, ferritin, etc.), and microbes in their native, attenuated, engineered, or inactivated forms. A deeper understanding of how the difference in the spatial or temporal distribution of antigens or adjuvants would influence the immune system at organ/tissue/cellular/subcellular levels and dynamically for specialized adaptive immune response induction and maintenance might provide novel insights for the rational design of better vaccines.
This Research Topic aims to provide a forum to stimulate critical and creative thinking and showcase advanced research on the immunological mechanisms of vaccine delivery systems. Subtopics include but are not limited to the following:
1) Novel designs targeting specific organs/tissues/cells/subcellular compartments
2) Mucosal vaccine delivery
3) Novel designs for temporal control of antigen/adjuvant delivery
4) The effect and mechanism of delivery systems on antigen processing and presentation
5) The effect and mechanism of delivery systems on adjuvant function
6) Novel stromal or immune cell subsets important for specialized T/B cell response, including long-term memory
7) Comparison of landscapes, at multiple levels, of the immune system upon different vaccine deliveries
