Research Topic

Role of TRP Channels in Endocrinology

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TRP (Transient Receptor Potential) is a superfamily of 28 membrane proteins that share structural and functional similarity. They are known as cellular sensors and play critical roles in the formation of sight, hearing, touch, smell, taste and temperature and pain sensation. This superfamily of cation ...

TRP (Transient Receptor Potential) is a superfamily of 28 membrane proteins that share structural and functional similarity. They are known as cellular sensors and play critical roles in the formation of sight, hearing, touch, smell, taste and temperature and pain sensation. This superfamily of cation channels can be activated by a variety of chemical and physical stimuli and function as signal integrators.

Ca2+ homeostasis and the associated cellular processes are tightly regulated by TRP channels. Therefore, these channels are often involved in regulation of downstream effectors sensitive to changes in intracellular Ca2+ such as controlling survival, proliferation, migration, cell motility and secretion. These properties give rise to the appreciation of the important contributions that TRP channels make to physiology and pathophysiology.

Increasing evidence has implicated TRP channels in the physiology of different organs such as kidney, heart, pancreas and respiratory system and pathophysiology of different diseases such as diabetes, cancer, tumorigenesis, cardiovascular, renal and respiratory tract dysfunctions.

This Research Topic will focus on TRP channels involvement in regulation of cell signaling in endocrine system and pathology of endocrine diseases. We encourage interested electrophysiologists, endocrinologists, and biologists to submit mini-reviews, methods papers, review articles, perspectives, and original research articles covering this diverse topic.


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