About this Research Topic
Gain or loss of membrane surface expression of ion channels induced by abnormal subcellular trafficking is due to disease-related ion channel mutations or altered signalling pathways under pathophysiological conditions. However, the exact subcellular trafficking cycle is not clear for most of the ion channels, which hinders the treatment of cardiac diseases related to ion channel trafficking. The goal of this research topic is to advance the basic understanding of ion channel trafficking, discover new endogenous regulators, and develop novel small molecules targeting cardiac ion channels to correct dysregulated subcellular trafficking, aiming to promote the treatment of cardiac diseases related to ion channel trafficking.
We welcome submissions on the following subtopics, but not limited to:
- Novel variants of ion channels inducing abnormal subcellular trafficking
- Super-resolution or real-time imaging of ion channels in specific subcellular membrane domains
- Post-translational modification of ion channels affecting subcellular trafficking and related functional kinases
- Mechanisms of ion channel co-trafficking
- Small molecules correcting deficient subcellular trafficking of ion channels
- Case reports of novel ion channel mutations identified from patients with cardiac disease, such as long QT syndrome, Brugada syndrome and catecholaminergic polymorphic ventricular tachycardia
- New methods for quantification of the rates of ion channel subcellular trafficking
Keywords: ion channel, subcellular trafficking, cardiac disease, mutation, signalling pathway
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