About this Research Topic
This set of publications aims to highlight the latest experimental methods and protocols used in the New Approach Methodologies field of research (NAMS), particularly methods that minimize or remove the need for animal testing. Review articles or opinions on methodologies or applications including the advantages and limitations of each are welcome. This topic includes technologies and up to date methods and schedules which help advance the science.
The contributions to this collection will undergo peer-review. Novelty may vary, but the utility of a method or protocol must be evident. We welcome contributions covering all aspects of the utility of NAMS in both the pharmaceutical, pesticide, and chemical industries. Submissions will be handled by the team of Topic Editors in the respective sections.
Over the past years, significant progresses have been made regarding the use of in vitro tests to identify chemicals and drugs altering immune functions and increasing sensitivity to cancers, autoimmune diseases, and infections (for example). In that time, tremendous advancements have been made in NAMS bioassays which require an update to the current state of the science.
This Research Topic on Methods and Protocols is dedicated to NAMS in Developmental and Reproductive Toxicology. We are specifically looking for:
• Reviews highlighting the interests and limits of current in vitro tests using NAMS to predict developmental and reproductive toxicology effects (DART) effects.
• New in vitro or in silico methods/protocols applying NAMS to DART assessment.
• Perspectives on implementation of genetics, epigenetics, proteomics, bioinformatics and system biology for evaluating hazard using NAMS.
• Commentaries/Advances on new concepts and techniques arising from NAMS
development that can be translated in new bioassays and mode of action assessment.
• Systematic reviews identifying gaps and research needs in predictive NAMS.
• New AOP (Adverse Outcome Pathway) articles detailing use of AOPs as NAMS alternative assessment.
• Guidelines and recommendations for how to (i) use generated data for risk evaluation and (ii) validate new methods that remain confined in research laboratories.
The contributions to this collection will undergo peer-review. Novelty may vary, but the utility of a method or protocol must be evident. We welcome contributions covering all aspects of the utility of NAMS in both the pharmaceutical, pesticide, and chemical industries. Submissions will be handled by the team of Topic Editors in the respective sections.
Over the past years, significant progresses have been made regarding the use of in vitro tests to identify chemicals and drugs altering immune functions and increasing sensitivity to cancers, autoimmune diseases, and infections (for example). In that time, tremendous advancements have been made in NAMS bioassays which require an update to the current state of the science.
This Research Topic on Methods and Protocols is dedicated to NAMS in Developmental and Reproductive Toxicology. We are specifically looking for:
• Reviews highlighting the interests and limits of current in vitro tests using NAMS to predict developmental and reproductive toxicology effects (DART) effects.
• New in vitro or in silico methods/protocols applying NAMS to DART assessment.
• Perspectives on implementation of genetics, epigenetics, proteomics, bioinformatics and system biology for evaluating hazard using NAMS.
• Commentaries/Advances on new concepts and techniques arising from NAMS
development that can be translated in new bioassays and mode of action assessment.
• Systematic reviews identifying gaps and research needs in predictive NAMS.
• New AOP (Adverse Outcome Pathway) articles detailing use of AOPs as NAMS alternative assessment.
• Guidelines and recommendations for how to (i) use generated data for risk evaluation and (ii) validate new methods that remain confined in research laboratories.
Keywords: #CollectionSeries, in vitro, in silico, DART, NAMs
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
