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Manuscript Submission Deadline 03 September 2023

RNA-Protein Interactions play a crucial role in many biological processes in all organisms. These interactions are very dynamic in nature as the composition of the Ribonucleoprotein (RNP) complexes varies according to the maturation or the functional state of RNA as well as the cellular context. Such flexible and dynamic RNA-Protein binding regulates the precession of the cellular response to stress and signaling. Therefore, any misregulation and disruption of the features of RNA or RNA-binding protein may lead to several diseases including diabetes, cardiovascular disease, and disorders such as neurodegenerative disease. Recent studies have shown that RNA-Protein interaction can serve as an attractive target for precision medicine therapies.

RNA-binding protein interacts with RNA and regulates various RNA processes such as RNA stability, alternative pre-mRNA splicing, mRNA decay, translocation, and post-translational nucleotide modification. Proper regulation of this interaction is required to maintain the balance between normal function and dysfunction. Targeting this interaction is a challenging task and the identification of novel RNA-Protein interaction modulators requires an attractive strategy to develop new therapeutics for complex diseases. A lot of progress in this area has been made recently, by identification of a druggable pocket in RNA-binding interfaces, accumulating structural and cellular data from both advanced computational, and experimental techniques for the development of small molecules that target RNA-Protein interactions.

The aims of this Research Topic are to update the current understanding and future directions of RNA-Protein interaction, how these interactions are regulated in diseased conditions, and how these interactions can be modulated. The scope covers all relevant technologies and topics, from molecular and cellular studies, to animal and human research as well as in silico approaches.

We will be happy to consider original articles, reviews, perspectives, and commentaries related to all facets of Protein-RNA interaction. We welcome contributions that cover, but are not limited to, the following themes:

• How RNA-Protein interaction is regulated by RNA and Protein structure,
• Mechanistic roles that the RNA-binding protein plays in disease
• Discovery of new tools to study Protein-RNA interaction in vitro and in vivo, targeting RNA-Protein interaction in
live cell.
• In silico strategies to identify RNA-protein interaction modulators
• Application of RNA-protein interaction modulators to treat complex diseases

Keywords: RNA-binding protein, RNA-Protein Interactions, Protein structure, RNA structure, RNA-protein modulators


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

RNA-Protein Interactions play a crucial role in many biological processes in all organisms. These interactions are very dynamic in nature as the composition of the Ribonucleoprotein (RNP) complexes varies according to the maturation or the functional state of RNA as well as the cellular context. Such flexible and dynamic RNA-Protein binding regulates the precession of the cellular response to stress and signaling. Therefore, any misregulation and disruption of the features of RNA or RNA-binding protein may lead to several diseases including diabetes, cardiovascular disease, and disorders such as neurodegenerative disease. Recent studies have shown that RNA-Protein interaction can serve as an attractive target for precision medicine therapies.

RNA-binding protein interacts with RNA and regulates various RNA processes such as RNA stability, alternative pre-mRNA splicing, mRNA decay, translocation, and post-translational nucleotide modification. Proper regulation of this interaction is required to maintain the balance between normal function and dysfunction. Targeting this interaction is a challenging task and the identification of novel RNA-Protein interaction modulators requires an attractive strategy to develop new therapeutics for complex diseases. A lot of progress in this area has been made recently, by identification of a druggable pocket in RNA-binding interfaces, accumulating structural and cellular data from both advanced computational, and experimental techniques for the development of small molecules that target RNA-Protein interactions.

The aims of this Research Topic are to update the current understanding and future directions of RNA-Protein interaction, how these interactions are regulated in diseased conditions, and how these interactions can be modulated. The scope covers all relevant technologies and topics, from molecular and cellular studies, to animal and human research as well as in silico approaches.

We will be happy to consider original articles, reviews, perspectives, and commentaries related to all facets of Protein-RNA interaction. We welcome contributions that cover, but are not limited to, the following themes:

• How RNA-Protein interaction is regulated by RNA and Protein structure,
• Mechanistic roles that the RNA-binding protein plays in disease
• Discovery of new tools to study Protein-RNA interaction in vitro and in vivo, targeting RNA-Protein interaction in
live cell.
• In silico strategies to identify RNA-protein interaction modulators
• Application of RNA-protein interaction modulators to treat complex diseases

Keywords: RNA-binding protein, RNA-Protein Interactions, Protein structure, RNA structure, RNA-protein modulators


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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