About this Research Topic
Alterations of vascular architecture and function represent a common manifestation of most cardiovascular disease. The knowledge of biological mechanisms governing the vascular response to stress is critical to both the growth and repair of tissues as well as for the progression of several pathologies. Several progress in the field of vascular biology have been made so far and our molecular understanding of vascular growth has facilitated the development of novel innovative therapies that have been successfully applied in cardiovascular. One of the most recent and exciting field of investigation in biology concerns molecular modifications occurring beyond the genetic framework called “epigenetic” modifications. Epigenetics has emerged as one of the most promising areas that will address some of the gaps in our current knowledge of the interaction between nature and nurture in the development of several cardiovascular diseases. Notwithstanding these advancements, much remains to be harnessed from the basic epigenetic mechanisms that control vascular function.
For this Research Topic, we welcome investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular mechanisms underlying epigenetic paradigm in vascular disease, the development of strategies to treat these conditions, and the evaluation of outcomes.
We are particularly interested in articles describing advances in molecular genetics and molecular diagnostics; new insights into vascular disease using animal models; current concepts in the treatment of vascular alterations using epigenetic drugs (HDACi, demethylating agents etc.), small molecules and non-coding RNAs.
Keywords: epigenetics, vascular disease, angiogenesis, cardiovascular alterations, metabolism
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