About this Research Topic
Cardiovascular disease is the leading cause of worldwide death. Increasing age is an independent risk factor for cardiovascular disease. Substantial evidence supports the senescent cells accumulated with age as the key driver of cardiac aging and contributes to age-related cardiovascular disease such as atherosclerosis and heart failure. However, several issues remain to be resolved to gain further insight into cellular senescence in heart disease and to translate the related discoveries to clinical application. (1) Information on cellular senescence in a number of common heart diseases such as congenital heart disease and cardiac arrhythmia remains limited. (2) The understanding of the mechanisms that cellular senescence is regulated in the heart is incomplete. (3) Although several markers of cellular senescence are discovered, no single marker is reliable to detect cellular senescence especially in vivo. In addition, postmitotic cardiomyocytes may have unique features of cellular senescence such as distinct profiles of senescence-associated secretory phenotype. Thus, discovery of novel markers for cellular senescence especially in the heart will advance this field. Moreover, it remains to be determined whether there are markers of cellular senescence that can be served as biomarkers for molecular diagnosis of heart disease or predictors of cardiovascular prognosis. (4) Cellular senescence can be targeted to treat age-related heart disease. However, the feasibility of the therapeutic approaches requires further investigation.
In this Research Topic, we aim to create a forum for the dissemination of the latest findings concerning the roles of cellular senescence in heart disease, the underlying molecular and cellular mechanisms by which cellular senescence is regulated in the heart, and the potential clinical applications of the findings concerning cellular senescence in diagnosis and therapy of heart disease.
We welcome research articles, review articles, brief research reports and case reports on the following topics but are not limited to:
- The roles of cellular senescence in cardiac development, cardiac repair and regeneration, cardiac aging, and cardiac diseases such as congenital heart disease, cardiac arrhythmia, cardiotoxicity, hypertensive heart disease, diabetic heart disease, ischemic heart disease, and valvular disease
- Molecular pathways and intercellular communication between cardiomyocyte and non-cardiomyocyte that regulate cellular senescence in the heart
- Crosstalk between cellular senescence and other stress responses such as autophagy and cell death in the development of heart disease
- Novel biomarkers of cellular senescence and senescence markers that are potentially used as diagnostic or prognostic biomarkers for heart disease
- Therapeutics that target cellular senescence to treat heart disease
In this Research Topic, we aim to create a forum for the dissemination of the latest findings concerning the roles of cellular senescence in heart disease, the underlying molecular and cellular mechanisms by which cellular senescence is regulated in the heart, and the potential clinical applications of the findings concerning cellular senescence in diagnosis and therapy of heart disease.
We welcome research articles, review articles, brief research reports and case reports on the following topics but are not limited to:
- The roles of cellular senescence in cardiac development, cardiac repair and regeneration, cardiac aging, and cardiac diseases such as congenital heart disease, cardiac arrhythmia, cardiotoxicity, hypertensive heart disease, diabetic heart disease, ischemic heart disease, and valvular disease
- Molecular pathways and intercellular communication between cardiomyocyte and non-cardiomyocyte that regulate cellular senescence in the heart
- Crosstalk between cellular senescence and other stress responses such as autophagy and cell death in the development of heart disease
- Novel biomarkers of cellular senescence and senescence markers that are potentially used as diagnostic or prognostic biomarkers for heart disease
- Therapeutics that target cellular senescence to treat heart disease
Keywords: cellular senescence, heart disease, signal transduction, biomarker, therapeutics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
