About this Research Topic
The incidence of systemic infection known as sepsis is a potentially life-threatening complication that results in short and long-term brain injuries and dysfunctions. The hospital mortality rate of septic shock is remarkably high reaching almost 30% to 50%. Inflammatory and non-inflammatory processes of acute or chronic septic shock alter the integrity of the blood-brain barrier and induce neuronal injury, in addition to excessive glial inflammatory. Notably, brain accumulation of amyloid beta and tau have been described in septic patients. These responses increase the vulnerability to neurological disorders or aggravate the neurovascular or neurodegenerative disorders outcomes.
Clinical manifestations of sepsis include cognitive impairment, sepsis-associated encephalopathy, delirium, coma, and sickness behavior. Some survivors present sustained cognitive affectations after several years after the sepsis onset. Importantly, there is currently no specific treatment for the cognitive dysfunction associated with sepsis.
This Research Topic aims to broaden our understanding of the fundamental neuropathological mechanisms of sepsis and find therapeutic target options that may impact significantly on sepsis-induced neurologic outcomes. We welcome papers focused on, but not limited, to the following topics:
- Cellular and molecular mechanisms underlying the short and long-term cerebral effects of sepsis, such as blood-brain barrier dysfunction, brain inflammation, alterations in neural synapses, systemic inflammation, and changes in the neurovascular system.
- Possible therapeutic targets for short- and long-term brain injury in sepsis.
- Animal models to study neuropathological mechanisms in sepsis.
We particularly welcome submissions of Original Research, Reviews, Methods, and Perspective articles.
Clinical manifestations of sepsis include cognitive impairment, sepsis-associated encephalopathy, delirium, coma, and sickness behavior. Some survivors present sustained cognitive affectations after several years after the sepsis onset. Importantly, there is currently no specific treatment for the cognitive dysfunction associated with sepsis.
This Research Topic aims to broaden our understanding of the fundamental neuropathological mechanisms of sepsis and find therapeutic target options that may impact significantly on sepsis-induced neurologic outcomes. We welcome papers focused on, but not limited, to the following topics:
- Cellular and molecular mechanisms underlying the short and long-term cerebral effects of sepsis, such as blood-brain barrier dysfunction, brain inflammation, alterations in neural synapses, systemic inflammation, and changes in the neurovascular system.
- Possible therapeutic targets for short- and long-term brain injury in sepsis.
- Animal models to study neuropathological mechanisms in sepsis.
We particularly welcome submissions of Original Research, Reviews, Methods, and Perspective articles.
Keywords: sepsis, neuropathology, brain injury, sepsis-associated encephalopathy
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