About this Research Topic
Sepsis is a significant issue for world health since it is a life-threatening organ malfunction brought on by an unbalanced host response to infection. Sepsis costs more than 24 billion $/yearly in the USA and is the most frequent reason for hospital mortality. Sepsis incidence can be decreased through infection prevention measures, including those aimed at both community-acquired and healthcare-associated illnesses. Treatment for sepsis is available, and the timely application of focused therapies enhances results. Member states have been encouraged by the World Health Assembly to step up efforts to recognize, record, prevent, and treat sepsis. There is a high incidence of antimicrobial-resistant pathogens around the globe mainly in low-middle-income countries causing septicaemia in vulnerable patients. These pathogens are primarily resistant to first and second lines drugs and lead to increase mortality.
The emergence and spread of antimicrobial-resistant pathogens producing septicemia is a serious global health concern. The World Health Organization (WHO) estimated that 48.9 million cases of sepsis have been reported and that one person dies every 2.58 seconds around the world. Furthermore, 20 million cases were detected among children, with 2.9 million deaths worldwide and 85% of these deaths in developing countries. Additionally, an estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections and by 2050 one person will die every three seconds. It's the need of the hour to conduct more studies to determine the prevalence rate of AMR-producing septicaemia pathogens, associated risk factors, molecular epidemiology of the pathogens, microbial diversity and antibiotic usage in children.
In this Research Topic, we cover the burden of AMR pathogens, antimicrobial usage, sequence typing, associated risk factors, antimicrobial consumption, antimicrobial stewardship, behaviour, and attitude towards AMR related to paediatric septicaemia patients.
We welcome the submission of Original Research, Review, Mini Reviews, Clinical Trials, Case Reports and Brief Research Report articles.
The emergence and spread of antimicrobial-resistant pathogens producing septicemia is a serious global health concern. The World Health Organization (WHO) estimated that 48.9 million cases of sepsis have been reported and that one person dies every 2.58 seconds around the world. Furthermore, 20 million cases were detected among children, with 2.9 million deaths worldwide and 85% of these deaths in developing countries. Additionally, an estimated 1.2 million people died in 2019 from antibiotic-resistant bacterial infections and by 2050 one person will die every three seconds. It's the need of the hour to conduct more studies to determine the prevalence rate of AMR-producing septicaemia pathogens, associated risk factors, molecular epidemiology of the pathogens, microbial diversity and antibiotic usage in children.
In this Research Topic, we cover the burden of AMR pathogens, antimicrobial usage, sequence typing, associated risk factors, antimicrobial consumption, antimicrobial stewardship, behaviour, and attitude towards AMR related to paediatric septicaemia patients.
We welcome the submission of Original Research, Review, Mini Reviews, Clinical Trials, Case Reports and Brief Research Report articles.
Keywords: Antimicrobial Resistance, Paediatric infections, Septicaemia, Molecular epidemiology, Antimicrobial usage
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