About this Research Topic
Abdominal aortic aneurysm (AAA) is a common degenerative disease of the aorta which accounts for roughly one to three per cent of deaths among people aged between 65–85 years. AAA is mostly asymptomatic until the fatal incident of rupture and is associated with a higher risk of other major cardiovascular events such as myocardial infarction and stroke. Traditionally AAA is detected through imaging technologies which is often incidental when patients present for other health issues and surgically treated as per current guidelines if the aortic diameter is large (>50-55mm). Some countries have introduced screening programs that are able to identify AAAs at an early stage, but they offer no therapeutic option. There are no clinically validated circulating diagnostic or prognostic options available for AAA either. Therefore patients are continually monitored via regular clinical review and aortic diameter imaging which has implications for the wellbeing of patients and cost to the health sector. At present, rural and remote patients have limited access to these imaging technologies, a problem that would be solved with a simple but effective diagnostic assay. Blood borne diagnostic, prognostic and therapeutic markers are expected to provide a more effective management strategy for AAA within the primary health-care system. Medication impeding small AAA progression would limit the number of patients requiring AAA surgery and would have potential patient and cost benefits. Therefore, the focus of this Research Topic is to explore the emerging diagnostic and therapeutic options for AAA that could be readily available, cost-effective and improve disease management.
Keywords: abdominal aortic aneurysm, radiation, biomarkers, diagnosis, therapy
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