Research Topic

Is the Recent Burst of Therapeutic Anti-Tumor Antibodies the Tip of an Iceberg?

  • Submission closed.

About this Research Topic

Clinically approved anti-tumor antibodies identify a restricted set of surface antigens on either the cancer cells, or on other cells directly or indirectly interacting with the neoplastic cells. Others, however, recognize antigens from soluble extracellular molecules participating in processes required for ...

Clinically approved anti-tumor antibodies identify a restricted set of surface antigens on either the cancer cells, or on other cells directly or indirectly interacting with the neoplastic cells. Others, however, recognize antigens from soluble extracellular molecules participating in processes required for tumor development. This, together with the recent therapeutic success using antibodies against immunological checkpoints, which were able to reprogram the host anti-tumor immune response, and therefore increase the disease-free period on many patients, make us fully aware of the enormous potential of antibody-based cancer therapies.

In this Research Topic, we would like to discuss the burst on basic research, preclinical studies and new clinical applications as a consequence of the high discovery rate of additional/new molecules involved in tumor progression and the high effectiveness of Abs as therapeutic agents. In particular, we would like to discuss i) the different mechanisms used by these antibodies to modulate the anti-tumor immune response; ii) the generation of new antibodies identifying intracellular antigens (i.e. peptides loaded onto HLA class I molecules); and iii) the use of antibody cocktails, either recognizing different epitopes of a given antigen, or identifying different molecules over-expressed in particular tumors. This approach is especially relevant when the aim is to target cancer stem cells (CSC), for the lack of CSC-specific cell surface markers, making it difficult the use of antibodies to kill them.

Taken together, these issues lead to a nearly unimaginable expansion of the field of antibody-based therapies, allowing to envisage durable remissions after acute treatments, avoiding chronic treatments.


Keywords: therapeutic antibodies, tumor progression antigens, tailor-made antibody formats, antibody cocktails


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Recent Articles

Loading..

About Frontiers Research Topics

With their unique mixes of varied contributions from Original Research to Review Articles, Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author.

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..

Topic Editors

Loading..

Submission Deadlines

Submission closed.

Participating Journals

Loading..
Loading..

total views article views article downloads topic views

}
 
Top countries
Top referring sites
Loading..

Comments

Loading..

Add a comment

Add comment
Back to top