About this Research Topic
Physical activity, as seen in endurance or resistance exercise, challenges whole-body homeostasis, demanding an orchestrated systemic response permitting to equilibrate metabolic demands of contracting skeletal muscles. Adaptation to exercise is associated with whole-body health as exercise increases oxidative capacity, muscle mass, strength, and metabolic health.
In contrast, physical inactivity unloads muscle, negatively affecting musculoskeletal health, and reversing the aforementioned health-related benefits. Furthermore, prolonged disuse of muscle leads to a decline in glucose tolerance and insulin sensitivity, a decrease in resting fat oxidation, increased reactive oxygen species production, and disrupting metabolic rate, which is associated with increased morbidity and mortality. In addition, physical inactivity is recognized as a compounding factor in sarcopenia. Therefore, exercise is medicine.
For precision-medicine, the personalization of exercise is still lacking. Epigenetic factors could be regarded as potential biomarkers allowing for the prediction of exercise outcomes. Thus, epigenetics could be used to exploit the personal potential of adaptations to exercise.
We aim to publish a collection of articles (Original Research, Review, Mini Review, Brief Research Reports, Perspective, Conceptual Analysis and Opinion) that cover one or more of the following themes:
• Influences of endurance and/or resistance exercise-induced epigenetics changes on the biological age
• Potential epigenetic factors that could be used as biomarkers to predict exercise outcomes
• The role of epigenetics in endurance and/or resistance exercise
• Dose-response relationships on epigenetic markers in endurance and/or resistance exercise
• Implications of acute vs chronic exercise on epigenetics
• Epigenetic implications on exercise metabolism
• Influence of epigenetic modifications on key exercise signaling pathways and networks
• Endurance and/or resistance exercise-induced epigenetic changes and outcome predictions
• Influence of exercise performance enhancing supplements on biological age
• Distinct endurance and/or resistance exercise-induced epigenetic markers
• Resistance exercise-induced epigenetic changes predicting muscle mass increase
• Epigenetic markers correlating with myofibrillar protein synthesis
• Epigenetic markers that can be used for the personalization of exercise recommendations
• Epigenetic differences in world-class athletes vs non-athletes
In contrast, physical inactivity unloads muscle, negatively affecting musculoskeletal health, and reversing the aforementioned health-related benefits. Furthermore, prolonged disuse of muscle leads to a decline in glucose tolerance and insulin sensitivity, a decrease in resting fat oxidation, increased reactive oxygen species production, and disrupting metabolic rate, which is associated with increased morbidity and mortality. In addition, physical inactivity is recognized as a compounding factor in sarcopenia. Therefore, exercise is medicine.
For precision-medicine, the personalization of exercise is still lacking. Epigenetic factors could be regarded as potential biomarkers allowing for the prediction of exercise outcomes. Thus, epigenetics could be used to exploit the personal potential of adaptations to exercise.
We aim to publish a collection of articles (Original Research, Review, Mini Review, Brief Research Reports, Perspective, Conceptual Analysis and Opinion) that cover one or more of the following themes:
• Influences of endurance and/or resistance exercise-induced epigenetics changes on the biological age
• Potential epigenetic factors that could be used as biomarkers to predict exercise outcomes
• The role of epigenetics in endurance and/or resistance exercise
• Dose-response relationships on epigenetic markers in endurance and/or resistance exercise
• Implications of acute vs chronic exercise on epigenetics
• Epigenetic implications on exercise metabolism
• Influence of epigenetic modifications on key exercise signaling pathways and networks
• Endurance and/or resistance exercise-induced epigenetic changes and outcome predictions
• Influence of exercise performance enhancing supplements on biological age
• Distinct endurance and/or resistance exercise-induced epigenetic markers
• Resistance exercise-induced epigenetic changes predicting muscle mass increase
• Epigenetic markers correlating with myofibrillar protein synthesis
• Epigenetic markers that can be used for the personalization of exercise recommendations
• Epigenetic differences in world-class athletes vs non-athletes
Keywords: personalize, exercise, epigenetics, biomarkers
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