About this Research Topic
The prevalence of cardiovascular diseases(CVD) and type 2 diabetes (Type 2 DM) has increased dramatically over the past 3 decades. Globally, both non-communicable diseases(NCD) are projected to increase and indeed double by 2030. Consequently, CVD and Type 2 DM will be among the leading causes of deaths in racial/ethnic populations in diverse geographic locations. The reasons for the increasing epidemic of CVD and Type 2 DM remain debatable. Therefore, it is imperative to examine the genetic, molecular, and metabolic as well as social determinants of CVD and Type 2DM among racial and ethnic populations. In this context, the major risk factors for CVD and its outcomes include diabetes, hypertension, lipids / lipoprotein disorders , physical inactivity and obesity. Thus, studies on genetic and epigenetic markers, as well as environmental factors that mediate CVD and Type 2DM are needed.
It is well established that insulin resistance constitutes a major pivotal lesion underlying CVD , Type 2 DM and metabolic syndrome. In this regard, it is well established that, obesity has become a major common pivotal disorder affecting both diseases. Of a major concern, obesity has become a global epidemic in both developed and developing countries. Furthermore, there is increasing recognition that, apart from fat storage, adipose tissue is the largest endocrine organ that produces several humoral factors (adipocytokines) that mediate CVD and Type 2 DM, and hypertension as well as increase thrombosis and subclinical inflammation among ethnic and racial populations. Furthermore, obesity and the intraabdominal visceral fat distribution vary among racial and ethnic populations residing in diverse locations. These metabolic phenomena affect both native, indigenous and immigrant racial and ethnic populations. Thus, the understanding of ethnic and racial differences in CVD and Type 2 DM could provide insights into the prevention, and treatment of CVD and Type 2DM. Therefore, we will welcome experts across the globe to discuss genetic, molecular, metabolic and environmental determinants of glucose/insulin metabolism, insulin resistance, and beta cell secretion as well as lipid and lipoprotein metabolism. Thus, we propose a series of review articles that are aimed at defining unique perspectives and insights underlying CVD, and Type 2DM in racial and ethnic populations residing in diverse geographic locations. We believe, novel strategies for prevention and treatment of CVD and Type 2DM will have huge public health and economic implications, especially in developing countries. Given the interest in the Research Topic, we will welcome review manuscripts from authors interested in this area.
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