About this Research Topic
This Research Topic aims at fostering basic, applied, and clinical research insights into innovative bio-nano-materials and translational advancements in soft and hard tissue bio-management strategies and possibilities (5R’s: Reconstruction, Restoration, Replacement, Repair and/or Regeneration), herein, with a special focus on the cranio-maxillo-facial complex. We aspire to provoke multi-disciplinary research, development, and innovation to ultimately improve the so far un-satisfactory/sub-par prevention, palliative, management, and/or treatment options available for our patients suffering from tissue lesions and defects. Hence, it is essential to discuss discoveries in cellular and molecular signaling pathways, artificial intelligence, biomimicry, three-dimensional printing and biotechnology, innovative nanomaterials and biopolymers designed, synthesized, incorporated, and used in formulating novel and release-controlled drug (cell-, gene-, protein-, amongst others) delivery systems, pharmaceutics, scaffolds, hydrogels, and matrices for translational and spatiotemporal application in nano-medicine and dentistry, as well as addressing their limitations (despite receiving US-FDA approval, as is in some cases).
We welcome articles to discuss the different types of nanomaterials and biopolymers used, their preparation methods, safety and efficacy analysis, and potential translation from benchtop to bed-/chair-side. Contributions discussing different characterization methodologies and/or advanced strategies as well as any arising hurdles, including regulatory affairs, are also welcome. Therefore, we encourage the submission of insightful case reports, state-of-the-art reviews and mini-reviews, as well as original research articles dealing with basic, translational, or clinical studies on (but not limited to) the following sub-topics:
• New discovery of cranio-maxillo-facial and oro-dental biology biomarkers, cytokines, mesenchymal stromal cells, or cellular/molecular pathways involved in the repair and regeneration of skin, muscle, tendon, fascia, cartilage, or bone
• New design and characterization of biomaterials and matrices (including platelet concentrates) suitable for controlled or guided tissue regeneration and repair
• New application of advanced biomaterials and cell/tissue engineering methods (including multiple thrombopoietic agents, for example) in the management and treatment of cranio-maxillo-facial and oro-dental defects
• New application of biomimicry and additive manufacturing (with inflammatory and vascularization regulation, for example) in the induced healing process
• New utilization of biomaterial(s) and tissue engineering strategies, including osteoimmunology and densification, in tissue regeneration and repair
• Computational modeling for cells or cellular and molecular micro-environment(s) in the progress and/or acceleration of in situ tissue repair or regeneration
• Current approaches and challenges in translational cranio-maxillo-facial tissue engineering and regenerative medicine, from bench-top to bed- or chair-side
Keywords: 3D printing, additive manufacturing, biomaterials, biopolymer, bone defect bone regeneration, cell therapy, composite, craniomaxillofacial, dental, gene therapy, hybrid, hydrogel, innovation, osteogenesis, polymers, protein therapy, regenerative medicine, scaffolds, tissue engineering, tissue healing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.