About this Research Topic
Intestinal homeostasis depends on the complex interactions between the gut microbiota, intestinal epithelium, and host immune system, thus affecting many aspects of human health, including innate immunity, appetite, and energy metabolism. Polysaccharides exist widely in the diet and play a pivotal biological role in life activities through different pathways. In recent years, the gut microbiota has received increasing attention due to its critical role in host health and disease. Accumulated evidence suggests that dietary polysaccharides are the most potent modulators of intestinal homeostasis and are inextricably linked to chronic metabolic diseases such as obesity and type 2 diabetes and metabolic syndrome. For example, polysaccharides from I. obliquus reduced fasting blood glucose, improves intestinal barrier function, and restores the disrupted gut microbiota in diabetic mice, characterized by upregulation of Ki-67, ZO-1, and MUC2 expression in the intestine, also observed the restoration of the Firmicutes to Bacteroidetes ratio and the enrichment of beneficial bacteria such as Akkermansia and Lactobacillus. In diabetic patients, polysaccharides supplementation from Jerusalem artichokes could lower total cholesterol, LDL-cholesterol, triglycerides of plasma, and increase HDL-cholesterol concentrations.
This research topic aims to shed light on the mechanisms through which polysaccharides regulate intestinal homeostasis, helping to explain the effects of dietary polysaccharides on human health and disease.
We welcome submissions from the following topics, but do not accept submissions on pharmacology:
• Influence of dietary polysaccharides on chronic disease, including diabetes mellitus, hypertension, hyperlipidemia, stroke, obesity, heart disease, etc., by modulating the composition and function of the gut microbiota and thus affecting intestinal homeostasis, both in vitro and in vivo studies are acceptable.
• Isolation, identification, and characterization of potential dietary polysaccharides that can improve gut health by modulating intestinal homeostasis.
• Polysaccharides (alginate, carrageenan, gellan, etc.) used as food additive for their functional effects (water binding, emulsification, gel forming, etc.).
• Evaluation of dietary polysaccharides on enteric infectious disease, including salmonellosis, listeriosis, typhoid fever, cryptosporidiosis, cholera, etc., both animal model and human studies are acceptable.
This research topic aims to shed light on the mechanisms through which polysaccharides regulate intestinal homeostasis, helping to explain the effects of dietary polysaccharides on human health and disease.
We welcome submissions from the following topics, but do not accept submissions on pharmacology:
• Influence of dietary polysaccharides on chronic disease, including diabetes mellitus, hypertension, hyperlipidemia, stroke, obesity, heart disease, etc., by modulating the composition and function of the gut microbiota and thus affecting intestinal homeostasis, both in vitro and in vivo studies are acceptable.
• Isolation, identification, and characterization of potential dietary polysaccharides that can improve gut health by modulating intestinal homeostasis.
• Polysaccharides (alginate, carrageenan, gellan, etc.) used as food additive for their functional effects (water binding, emulsification, gel forming, etc.).
• Evaluation of dietary polysaccharides on enteric infectious disease, including salmonellosis, listeriosis, typhoid fever, cryptosporidiosis, cholera, etc., both animal model and human studies are acceptable.
Keywords: gut microbiota, polysaccharides, intestinal homeostasis, dietary nutrients
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
