About this Research Topic
Diabetes mellitus is considered a multifactorial, chronic metabolic disorder characterized by hyperglycemia owing to insulin resistance (IR) and insulin deficiency. Recent epidemiological data showed that diabetes affects people worldwide, reaching a prevalence of 412 million in 2015, with a plethora of these people having risk factors. Manifestations of Type 2 Diabetes (T2D) and IR occur carrying a series of immune responses that exacerbate the inflammatory state. Dysfunction of the immune system in type 2 diabetes is well recognized. Both innate immune response defects and dysfunction of the adaptive immune response are thought to be responsible for the immune systems weakness against invading pathogens in diabetic subjects. For that, cardiovascular complications of diabetes could be delayed by the comprehension of the molecular mechanisms regulating the immune dysfunctions.
This topic aims to decipher the immuno-molecular mechanisms involved in the development of cardiovascular complications of diabetes. It will be of great interest in order to consider advances in knowledge and alternative approaches based on recent development of mRNA therapies to be explored in clinical practice, hopefully offering a wider range of personalized therapeutic opportunities to an increasing number of patients.
This Research Topic will be accepted original and review article, with particular attention to the molecular themes when applied to cardiovascular complications of diabetes (type 1 and type 2), insulin resistance, ischemia, and fibrosis of heart and peripheral tissues. We welcome the following, but not limited to, sub topics:
• transcription factors
• alternative splicing
• applications of editing to reverse pathological phenotypes
• microRNAs and long-non coding
• mRNA-based therapy
This topic aims to decipher the immuno-molecular mechanisms involved in the development of cardiovascular complications of diabetes. It will be of great interest in order to consider advances in knowledge and alternative approaches based on recent development of mRNA therapies to be explored in clinical practice, hopefully offering a wider range of personalized therapeutic opportunities to an increasing number of patients.
This Research Topic will be accepted original and review article, with particular attention to the molecular themes when applied to cardiovascular complications of diabetes (type 1 and type 2), insulin resistance, ischemia, and fibrosis of heart and peripheral tissues. We welcome the following, but not limited to, sub topics:
• transcription factors
• alternative splicing
• applications of editing to reverse pathological phenotypes
• microRNAs and long-non coding
• mRNA-based therapy
Keywords: immune response, macrophages, neutrophils, adaptive immune response, T cells, insulin resistance, T2D, islets, microRNAs, long-non-coding RNAs, mRNA-based therapy, CRISPR, editing
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
