About this Research Topic
The microbiota, the collection of microbes that colonize barrier tissues, as well as the metabolites they produce, are essential for health. They help develop lymphoid structures, poise immune cells for responding to pathogens and foreign antigens and can guide immune differentiation, wound healing and tissue homeostasis. In transplantation, both intestinal microbiota and transplanted organ-associated microbiota can modulate alloimmunity. In addition, host anti-commensal responses, independently from alloresponses, can trigger damage of colonized organs. With both beneficial and detrimental effects of the microbiota and derived metabolites on transplant outcome, several investigators are working on strategies to modulate microbiota composition via diet, antibiotics, prebiotics, probiotics, or metabolite supplementation. This collection will compile primary papers and reviews on the impact of microbiota and metabolites on transplant outcomes, from pre-clinical to clinical studies.
As part of our journal’s mission to address key aspects of transplantation, including new avenues for transplantation methods, outcomes and treatment, Frontiers in Transplantation is organizing this Research Topic on Microbiota and Metabolites in Transplant Immunity: from Bench to Bedside.
The Research Topic will accept all article types/reviews/original research within this area of research, with the aim of giving the reader an overview of the latest discoveries on the microbiota and its metabolites in transplantation, including reviews of recent publications, new experimental, translational and clinical findings, new methods and protocols, and new opinions and perspectives.
Sub-themes for this Research Topic may include, but are not limited to:
1. Role of the intestinal microbiota on alloimmunity/transplant outcome
2. Role of graft-associated microbiome on alloimmunity/transplant outcome
3. Role of microbiota-derived metabolites on alloimmunity/transplant outcome
4. Longitudinal studies of microbiota/metabolites in transplant hosts
5. Interventional studies targeting the microbiota or derived metabolites
As part of our journal’s mission to address key aspects of transplantation, including new avenues for transplantation methods, outcomes and treatment, Frontiers in Transplantation is organizing this Research Topic on Microbiota and Metabolites in Transplant Immunity: from Bench to Bedside.
The Research Topic will accept all article types/reviews/original research within this area of research, with the aim of giving the reader an overview of the latest discoveries on the microbiota and its metabolites in transplantation, including reviews of recent publications, new experimental, translational and clinical findings, new methods and protocols, and new opinions and perspectives.
Sub-themes for this Research Topic may include, but are not limited to:
1. Role of the intestinal microbiota on alloimmunity/transplant outcome
2. Role of graft-associated microbiome on alloimmunity/transplant outcome
3. Role of microbiota-derived metabolites on alloimmunity/transplant outcome
4. Longitudinal studies of microbiota/metabolites in transplant hosts
5. Interventional studies targeting the microbiota or derived metabolites
Keywords: microbiota, alloimmunity, microbiome, microbiota-derived metabolites, transplant immunity
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
