About this Research Topic
Irritable bowel syndrome (IBS), a prevalent disorder of gut-brain interactions (DGBIs), has ignited interest in examining the role of luminal factors such as diet and gut microbiota in its development and management. Emerging evidence underscores the significant impact of dietary factors on IBS etiology and symptomatology, leading to the exploration of dietary interventions as a key therapeutic approach. Despite not always being supported by robust evidence, dietary interventions are experiencing a renaissance in managing irritable bowel syndrome.
Dietary components can modulate IBS symptoms through direct interactions with receptors of intestinal cells, including gut hormone release, epithelial morphology alterations, immune responses, and gut-brain-microbiota axis. The food we eat and the gut microbiota we harbor are integral to gut health, positioning dietary intervention as a promising avenue for fostering a healthy gut microbiota.
Recent research supports the benefits of low-FODMAP diets in alleviating IBS symptoms, while high-FODMAP diets exacerbate them. Vegetarian diets rich in fiber have been linked to increased short-chain fatty acid production, inhibiting pathogenic bacteria in the gut. To better understand IBS pathogenesis, it is crucial to investigate the intricate interplay between food, gut microbes, host immune response, and the perception of gastrointestinal events by the brain.
Food is a crucial determinant in shaping the gut microbiota profile. Moreover, evidence suggests that gut microbiota dysregulation is implicated in the pathogenesis of IBS, including visceral hypersensitivity, immune abnormalities, abnormal secretion, gut dysmotility, and impaired barrier dysfunction. Approximately 10% of IBS patients experience gastroenteritis-induced gut microbiota dysbiosis, highlighting the importance of dietary interventions and gut microbiota-targeted therapies. A comprehensive approach, encompassing multiomic data like dietary profiles, gut microbiome, metabolome, transcriptome, and host epigenome, is required to characterize IBS patients.
We invite submissions of all article types (original articles, reviews, and perspectives) to contribute to dietary interventions in IBS and their effects on the clinical profile and gut physiological and pathophysiological functions. This special issue aims to stimulate the development and implementation of dietary interventions to enhance IBS management and clinical care and to investigate the mechanistic and functional implications of the diet-gut microbiota-host interactions.
The main objectives and sub-themes of this special issue include, but are not limited to:
1. To investigate gut physiological and pathophysiological mechanisms of IBS, mediated directly by the food we eat or indirectly through interactions with gut microbiota.
2. To explore host-cell interactions with food components in modulating gut physiological and pathophysiological functions.
3. To identify effective dietary interventions for improving symptoms and pathogenesis of IBS.
4. To assess the impact of dietary intolerance and exclusion on IBS symptom severity and gut functions.
5. To address the current challenges and opportunities in diet-based therapeutic approaches for IBS.
Dietary components can modulate IBS symptoms through direct interactions with receptors of intestinal cells, including gut hormone release, epithelial morphology alterations, immune responses, and gut-brain-microbiota axis. The food we eat and the gut microbiota we harbor are integral to gut health, positioning dietary intervention as a promising avenue for fostering a healthy gut microbiota.
Recent research supports the benefits of low-FODMAP diets in alleviating IBS symptoms, while high-FODMAP diets exacerbate them. Vegetarian diets rich in fiber have been linked to increased short-chain fatty acid production, inhibiting pathogenic bacteria in the gut. To better understand IBS pathogenesis, it is crucial to investigate the intricate interplay between food, gut microbes, host immune response, and the perception of gastrointestinal events by the brain.
Food is a crucial determinant in shaping the gut microbiota profile. Moreover, evidence suggests that gut microbiota dysregulation is implicated in the pathogenesis of IBS, including visceral hypersensitivity, immune abnormalities, abnormal secretion, gut dysmotility, and impaired barrier dysfunction. Approximately 10% of IBS patients experience gastroenteritis-induced gut microbiota dysbiosis, highlighting the importance of dietary interventions and gut microbiota-targeted therapies. A comprehensive approach, encompassing multiomic data like dietary profiles, gut microbiome, metabolome, transcriptome, and host epigenome, is required to characterize IBS patients.
We invite submissions of all article types (original articles, reviews, and perspectives) to contribute to dietary interventions in IBS and their effects on the clinical profile and gut physiological and pathophysiological functions. This special issue aims to stimulate the development and implementation of dietary interventions to enhance IBS management and clinical care and to investigate the mechanistic and functional implications of the diet-gut microbiota-host interactions.
The main objectives and sub-themes of this special issue include, but are not limited to:
1. To investigate gut physiological and pathophysiological mechanisms of IBS, mediated directly by the food we eat or indirectly through interactions with gut microbiota.
2. To explore host-cell interactions with food components in modulating gut physiological and pathophysiological functions.
3. To identify effective dietary interventions for improving symptoms and pathogenesis of IBS.
4. To assess the impact of dietary intolerance and exclusion on IBS symptom severity and gut functions.
5. To address the current challenges and opportunities in diet-based therapeutic approaches for IBS.
Keywords: Irritable bowel syndrome (IBS), gut-brain interactions, gut microbiota, FODMAP diets, gut functions
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