About this Research Topic
The annual incidence of neurodegenerative disorders exponentially increases due to the aging of the global population. Understanding the complex networks of regulators is crucial to decipher neurodegenerative mechanisms and advance precise medicine. Gene networks can refer to different types of molecular interactions, including transcriptional regulatory networks, gene regulatory networks, protein-protein interaction network, miRNA-mRNA interaction, and so on. These networks can shed a light on pathological mechanisms involved in neurodegenerative disorders such as Alzheimer’s Disease and Parkinson’s Disease. The progressive and selective loss of neurons from different regions of the central nervous system characterizes the common neurodegenerative disorders. Despite the fact that many genetic factors have already been identified as regulators associated with toxicity, neuronal death, among other pathways, identifying the most important biomarker is still challenging.
There is a need for the discovery of accurate and effective biomarkers that can be used as therapeutic targets for treatment. The challenge of finding viable therapeutic targets can be attributed to the diversity of cells involved, the limited capacity for tissue regeneration, and the lack of understanding complex pathological processes and their regulatory mechanisms. Transcriptomics, proteomics, metabolomics, among other omics data analysis have enabled the prediction of novel interactions between different molecules. However, new approaches including integration of multi-omics regulatory network analysis can move us toward a more complete overview of the regulatory landscape and help to elucidate important mechanisms involved in neurodegenerative disorders.
This Research Topic aims to highlight innovative research that discusses the open questions related to regulatory mechanisms involved in any type of neurodegenerative disorder. This can be accomplished by utilizing different methods of gene network analysis. We welcome investigators to submit their Original Research, Brief Research Report, and Review articles.
Topics of interest include, but are not limited to:
• Use of computational systems biology approaches;
• Integration of computational methods including single-cell multi-omics network analysis;
• Application of machine learning algorithms to predict regulatory networks;
• Use of global interaction networks;
• Validation of predicted biomarkers for neurodegenerative disorders.
There is a need for the discovery of accurate and effective biomarkers that can be used as therapeutic targets for treatment. The challenge of finding viable therapeutic targets can be attributed to the diversity of cells involved, the limited capacity for tissue regeneration, and the lack of understanding complex pathological processes and their regulatory mechanisms. Transcriptomics, proteomics, metabolomics, among other omics data analysis have enabled the prediction of novel interactions between different molecules. However, new approaches including integration of multi-omics regulatory network analysis can move us toward a more complete overview of the regulatory landscape and help to elucidate important mechanisms involved in neurodegenerative disorders.
This Research Topic aims to highlight innovative research that discusses the open questions related to regulatory mechanisms involved in any type of neurodegenerative disorder. This can be accomplished by utilizing different methods of gene network analysis. We welcome investigators to submit their Original Research, Brief Research Report, and Review articles.
Topics of interest include, but are not limited to:
• Use of computational systems biology approaches;
• Integration of computational methods including single-cell multi-omics network analysis;
• Application of machine learning algorithms to predict regulatory networks;
• Use of global interaction networks;
• Validation of predicted biomarkers for neurodegenerative disorders.
Keywords: neurodegeneration network, molecular interactions, miRNA, Alzheimer Disease, Parkinson's Disease
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
