The role of Reactive Oxygen Species (ROS) in inflammation and Immunity has been well established. Specialized immune cells, such as neutrophils and macrophages are known to utilize ROS in the oxidative killing of engulfed microbial pathogens. However, ROS are key signaling molecules that can contribute to inflammation and regulation of inflammatory processes. Besides its role in the immune response to pathogens and protective immunity, increased ROS generation often has been linked to tissue injury, DNA damage, and the progression of many inflammatory and autoimmune diseases. Response to ROS signaling may be dependent on the genetic makeup of the individual, and this may in turn affect the diagnosis, therapeutic intervention, and prognosis of the disease. Through this theme, we aim to take a closer look at the contributions of ROS, and ROS–mediated signaling in immune disorders, inflammatory diseases, associated biomarkers, and their role in disease progression.
Since the advent of the COVID-19 pandemic, there has been a surge in the number of disease conditions and their symptoms that are ill-defined and poorly understood. These disease conditions or symptoms could be either directly or indirectly associated with COVID-19 or completely independent. However, one of the common factors in many of these could be ROS and oxidative stress, and it has been hypothesized that oxidative stress is associated with cytokine storm in patients affected with COVID-19. Besides COVID-19, there is now a rise in information on the role of ROS and ROS-mediated signaling in inflammatory and immune-mediated tissue injury and diseases of the heart, kidney, lungs, etc., and the therapeutics targeting redox balance associated with its etiology. However, there is a need for more such studies and strong scientific documentation to support and provide key data for the identification and development of diagnostic biomarkers and therapeutic targets.
In this Research Topic, we encourage the submission of manuscripts that address basic, translational, and clinical contributions towards:
• Understanding ROS signaling mechanisms affecting immunity.
• Involving the role of ROS-mediated inflammation and immunity in COVID-19 and other infectious diseases.
• Involving the role of ROS-mediated inflammation and immunity in tissue injury, vascular dysfunction, and angiogenesis.
• Redox stress signaling mediated modifications of proteins mRNAs, and microRNAs and their role in inflammation and immunity.
• Novel approaches for the identification of biomarkers for early diagnostics, clinical therapeutic approaches, genetic variations, and epigenetic changes.
This Research Topic will bring together the understanding of the paradigm shift in the field of redox signaling and immunity, to further deepen our understanding of immunological diseases and identify Biomarkers and therapeutic targets.
The role of Reactive Oxygen Species (ROS) in inflammation and Immunity has been well established. Specialized immune cells, such as neutrophils and macrophages are known to utilize ROS in the oxidative killing of engulfed microbial pathogens. However, ROS are key signaling molecules that can contribute to inflammation and regulation of inflammatory processes. Besides its role in the immune response to pathogens and protective immunity, increased ROS generation often has been linked to tissue injury, DNA damage, and the progression of many inflammatory and autoimmune diseases. Response to ROS signaling may be dependent on the genetic makeup of the individual, and this may in turn affect the diagnosis, therapeutic intervention, and prognosis of the disease. Through this theme, we aim to take a closer look at the contributions of ROS, and ROS–mediated signaling in immune disorders, inflammatory diseases, associated biomarkers, and their role in disease progression.
Since the advent of the COVID-19 pandemic, there has been a surge in the number of disease conditions and their symptoms that are ill-defined and poorly understood. These disease conditions or symptoms could be either directly or indirectly associated with COVID-19 or completely independent. However, one of the common factors in many of these could be ROS and oxidative stress, and it has been hypothesized that oxidative stress is associated with cytokine storm in patients affected with COVID-19. Besides COVID-19, there is now a rise in information on the role of ROS and ROS-mediated signaling in inflammatory and immune-mediated tissue injury and diseases of the heart, kidney, lungs, etc., and the therapeutics targeting redox balance associated with its etiology. However, there is a need for more such studies and strong scientific documentation to support and provide key data for the identification and development of diagnostic biomarkers and therapeutic targets.
In this Research Topic, we encourage the submission of manuscripts that address basic, translational, and clinical contributions towards:
• Understanding ROS signaling mechanisms affecting immunity.
• Involving the role of ROS-mediated inflammation and immunity in COVID-19 and other infectious diseases.
• Involving the role of ROS-mediated inflammation and immunity in tissue injury, vascular dysfunction, and angiogenesis.
• Redox stress signaling mediated modifications of proteins mRNAs, and microRNAs and their role in inflammation and immunity.
• Novel approaches for the identification of biomarkers for early diagnostics, clinical therapeutic approaches, genetic variations, and epigenetic changes.
This Research Topic will bring together the understanding of the paradigm shift in the field of redox signaling and immunity, to further deepen our understanding of immunological diseases and identify Biomarkers and therapeutic targets.
