About this Research Topic
Microvascular inflammation (MVI) after solid organ transplantation is often attributed to antibody- mediated rejection (AMR). However, MVI can also occur outside the context of AMR and in mixed or equivocal constellations. In addition, MVI is associated with inferior graft outcomes but currently available therapies have limited efficacy in attenuating the inflammation. Hence, many questions remain about the pathophysiology, clinical characteristics and optimal treatment of MVI after solid organ transplantation.
This research topic aims to acquire novel insights into the presence of MVI in all types of solid organ transplantation and related inflammation. These novel insights will help understand the pathogenesis of solid organ transplant diseases and could improve diagnostic classification, transplant patient care, and, ultimately, lead to novel therapeutic approaches.
The scope of this Research Topic is to elucidate different aspects of MVI after solid organ transplantation through a series of original articles and review articles. Themes of interest include, but are not limited to:
- Analysis of MVI and the reproducibility thereof
- Methodology and optimization of scoring and visualising MVI
- Humoral and non-humoral mechanisms of allorecognition leading to MVI
- Clinicopathological features of MVI associated with AMR, TCMR and mixed rejection
- Cellular effectors and inflammation pathways involved in various presentations of MVI
This research topic aims to acquire novel insights into the presence of MVI in all types of solid organ transplantation and related inflammation. These novel insights will help understand the pathogenesis of solid organ transplant diseases and could improve diagnostic classification, transplant patient care, and, ultimately, lead to novel therapeutic approaches.
The scope of this Research Topic is to elucidate different aspects of MVI after solid organ transplantation through a series of original articles and review articles. Themes of interest include, but are not limited to:
- Analysis of MVI and the reproducibility thereof
- Methodology and optimization of scoring and visualising MVI
- Humoral and non-humoral mechanisms of allorecognition leading to MVI
- Clinicopathological features of MVI associated with AMR, TCMR and mixed rejection
- Cellular effectors and inflammation pathways involved in various presentations of MVI
Keywords: Microvascular Inflammation, MVI, Antibody Mediated Rejection, Allorecognition, Solid Organ Transplantation, Graft Outcomes
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