About this Research Topic
Neuroinflammation, a protective response of the central nervous system (CNS), is associated with the pathogenesis of psychiatric disorders. Stressors including early-life adversity, psychosocial stress, genetic deficiency, and infection appear to trigger the release of various neuroinflammatory markers in both the peripheral circulation and the CNS. The subsequent inflammatory cascade will cause neuroinflammation to disrupt normal neurophysiological functions, and the dysregulation of pro-inflammatory mediators will eventually lead to a variety of mental diseases. As we gradually reveal the relationship between the immune and nervous system, identifying the potential neuroinflammatory markers may assist in the early diagnosis and detection of therapeutic targets for treating various psychiatric disorders.
The purpose of this research topic is to compile and discuss the latest research results and cutting-edge views on neuroimmune biomarkers of major psychiatric disorders, such as schizophrenia, depression, bipolar disorder, Alzheimer’s disease, and anxiety, using various cutting-edge molecular biology technologies and discipline theories. The identification of biomarkers of psychiatric disorders is helpful to reduce the ambiguity and randomness of diagnosis and treatment of such diseases and increase objectivity. Although many candidate markers have been proposed, due to the heterogeneity of psychiatric disorders, none of them has been approved for any clinical application of psychiatric disorders alone or in combination with biomarkers. This makes the research process challenging and promising.
1. Identification and potential clinical value evaluation of new peripheral immune markers for psychiatric disorders
2. The influence of immune factors on clinical drug treatment and non-drug treatment of psychiatric disorders
3. Pathological role of the molecular regulatory mechanism of neuroinflammation in the development of psychiatric disorders
4. The influence of genetic risk loci in psychiatric neuritis and its pathogenesis
5. Regulatory mechanism and potential clinical application of various epigenetic regulators on neuroinflammation-related genes
The purpose of this research topic is to compile and discuss the latest research results and cutting-edge views on neuroimmune biomarkers of major psychiatric disorders, such as schizophrenia, depression, bipolar disorder, Alzheimer’s disease, and anxiety, using various cutting-edge molecular biology technologies and discipline theories. The identification of biomarkers of psychiatric disorders is helpful to reduce the ambiguity and randomness of diagnosis and treatment of such diseases and increase objectivity. Although many candidate markers have been proposed, due to the heterogeneity of psychiatric disorders, none of them has been approved for any clinical application of psychiatric disorders alone or in combination with biomarkers. This makes the research process challenging and promising.
1. Identification and potential clinical value evaluation of new peripheral immune markers for psychiatric disorders
2. The influence of immune factors on clinical drug treatment and non-drug treatment of psychiatric disorders
3. Pathological role of the molecular regulatory mechanism of neuroinflammation in the development of psychiatric disorders
4. The influence of genetic risk loci in psychiatric neuritis and its pathogenesis
5. Regulatory mechanism and potential clinical application of various epigenetic regulators on neuroinflammation-related genes
Keywords: Neuroinflammation, CNS, neuroimmune, biomarker, molecular regulatory mechanism
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