About this Research Topic
Enzymes’ function depends amply on proper protein three-dimensional structure. The overall folding of proteins is based on a network of weak noncovalent interactions forming the different levels of protein structure organization. Protein structure, therefore, may change easily when minimum physical and chemical variations occur in the aqueous medium.
The present research topic focuses on work related to the study of mechanisms and kinetics of enzyme/protein inactivation and/or denaturation as well as on all the diverse strategies of enzyme stabilization that are a result of nature’s evolution as well as those developed and implemented in scientific laboratories and diverse industries.
This research topic encourages the submission of papers that cover current research whether experimental, theoretical or in silico of the mechanisms of protein inactivation and stabilization considering with an emphasis of works that provide a deep physical/mathematical analysis:
• Enzyme inactivation
• Protein folding/unfolding
• Inactivation mechanism and kinetics
• Enzyme stabilization & mechanisms
• Use and applications of stabilized enzymes/proteins
We welcome submissions of the following article types: Brief Research Report, General Commentary, Hypothesis & Theory, Methods, Mini Review and Review, Original Research, and Perspective.
Keywords: Enzyme Inactivation, Protein Unfolding, Protein Stability, Inactivation Mechanism, Inactivation Kinetics
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.