It is common ground that all cells require nutrients to develop, differentiate, and maintain their inherent activities. However, the idea that cells can rapidly alter their metabolism to perform specific functions under the pressure of different microenvironments was just brought to the light. These changes are particularly important for immune cells, as they need to respond quickly to opportunistic pathogens or tissue damage and prevent their spread. The field that investigates the interplay between immunology and metabolism is so-called immunometabolism and has supported the hypothesis that all diseases have a metabolic aspect.
The field of immunometabolism has multiple facets of investigation, such as the identification of metabolic sensors and moonlightning enzymes, the comprehension of how metabolites interfere with other non-metabolic signaling pathways, the understanding of how inflammatory molecules can impair metabolism-programmed immune responses, and the establishment of different axes such as microbiota-immunometabolism, endocrine system-immunometabolism, and central nervous system-immunometabolism.
As a new layer of cellular regulation, this field of research requires a revisit of old concepts while offering a plethora of novel possibilities for investigation and development of new treatments for virtually any disease, including infectious diseases, chronic inflammation, and cancer.
This Research Topic welcomes the contribution of Original Research, Review, Mini-review, Hypothesis and Theory, and Perspective articles on Immunometabolism, including, but not limited to, the metabolic needs or disturbances of immune cells in health and disease, how nutrients or nutrition shape immune responses, the potential immune-mediated links between metabolic diseases with the development and progression of cancer or other inflammatory diseases, and how the microbiota impact immunometabolism.
It is common ground that all cells require nutrients to develop, differentiate, and maintain their inherent activities. However, the idea that cells can rapidly alter their metabolism to perform specific functions under the pressure of different microenvironments was just brought to the light. These changes are particularly important for immune cells, as they need to respond quickly to opportunistic pathogens or tissue damage and prevent their spread. The field that investigates the interplay between immunology and metabolism is so-called immunometabolism and has supported the hypothesis that all diseases have a metabolic aspect.
The field of immunometabolism has multiple facets of investigation, such as the identification of metabolic sensors and moonlightning enzymes, the comprehension of how metabolites interfere with other non-metabolic signaling pathways, the understanding of how inflammatory molecules can impair metabolism-programmed immune responses, and the establishment of different axes such as microbiota-immunometabolism, endocrine system-immunometabolism, and central nervous system-immunometabolism.
As a new layer of cellular regulation, this field of research requires a revisit of old concepts while offering a plethora of novel possibilities for investigation and development of new treatments for virtually any disease, including infectious diseases, chronic inflammation, and cancer.
This Research Topic welcomes the contribution of Original Research, Review, Mini-review, Hypothesis and Theory, and Perspective articles on Immunometabolism, including, but not limited to, the metabolic needs or disturbances of immune cells in health and disease, how nutrients or nutrition shape immune responses, the potential immune-mediated links between metabolic diseases with the development and progression of cancer or other inflammatory diseases, and how the microbiota impact immunometabolism.
