About this Research Topic
The occurrence, development, recurrence, and drug resistance of hematological malignancies are closely related to the heterogeneity of the microenvironment. Hematologic malignancy and its microenvironment interact with each other to promote the malignant process of hematologic malignancy. Therefore, it is meaningful to study the changes in the microenvironment in hematologic malignancies and the molecular mechanism of microenvironment changes that play a positive role in relapse resistance of hematologic malignancies. It may be beneficial to improve the remission rate of hematologic malignancies and to reduce their relapse resistance by acting on the key molecules, and further providing ideas for the precise treatment of hematological malignant tumors.
The goal of this Research Topic is:
1. Our research is intended to explore the key mediators of the "communication" between the microenvironment of hematologic malignancies and tumor cells, and the molecular mechanism of its biological function leading to the occurrence, development, recurrence, and drug resistance of hematologic malignancies. And on this basis, new combined chemotherapy regimens will be explored to increase the sensitivity of hematological malignancies to treatment, to achieve the goal of reducing drug resistance of hematological malignancies.
2. The role of tumor microenvironment in different stages of hematologic malignancies may be heterogeneous, which may provide an accurate reference for tumor-stratified treatment. Therefore, the analysis of the multilevel structure of hematological malignancies and its microenvironment, the understanding of the evolution of the multi-scale structure and functional units at each level, and the interpretation of the regulation mechanism of the multilevel and multi-scale complex system of hematological malignancies and microenvironment will play a positive role in clarifying the dynamic change law of the evolution of hematological malignancies and the precise treatment of hematological malignancies.
Submissions should actively explore the regulation role and intervention strategies of the intermediate state of the transition of tumor microenvironment from physiological to pathological state in the occurrence and evolution of hematologic malignant tumors. That is to study the intermediate state of tumor microenvironment from normal to abnormal, from benign to malignant, and from treatment sensitivity to drug tolerance, which affects the competition and coordination among various leading mechanisms in the occurrence and evolution of hematologic malignant tumors, further study its regulatory mechanism and intervention strategies. This provides an original and new idea for the prevention and precision treatment of hematological malignancies.
The goal of this Research Topic is:
1. Our research is intended to explore the key mediators of the "communication" between the microenvironment of hematologic malignancies and tumor cells, and the molecular mechanism of its biological function leading to the occurrence, development, recurrence, and drug resistance of hematologic malignancies. And on this basis, new combined chemotherapy regimens will be explored to increase the sensitivity of hematological malignancies to treatment, to achieve the goal of reducing drug resistance of hematological malignancies.
2. The role of tumor microenvironment in different stages of hematologic malignancies may be heterogeneous, which may provide an accurate reference for tumor-stratified treatment. Therefore, the analysis of the multilevel structure of hematological malignancies and its microenvironment, the understanding of the evolution of the multi-scale structure and functional units at each level, and the interpretation of the regulation mechanism of the multilevel and multi-scale complex system of hematological malignancies and microenvironment will play a positive role in clarifying the dynamic change law of the evolution of hematological malignancies and the precise treatment of hematological malignancies.
Submissions should actively explore the regulation role and intervention strategies of the intermediate state of the transition of tumor microenvironment from physiological to pathological state in the occurrence and evolution of hematologic malignant tumors. That is to study the intermediate state of tumor microenvironment from normal to abnormal, from benign to malignant, and from treatment sensitivity to drug tolerance, which affects the competition and coordination among various leading mechanisms in the occurrence and evolution of hematologic malignant tumors, further study its regulatory mechanism and intervention strategies. This provides an original and new idea for the prevention and precision treatment of hematological malignancies.
Keywords: Hematological malignancies, Tumor microenvironment, heterogeneity, drug resistance, Relapsing resistance
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