About this Research Topic
Genitourinary tumor, as one of the most common malignant tumors in the world, deserves high attention for their high morbidity and mortality rates. Different mechanisms are involved in cancer development and progression. The tumor microenvironment (TME) includes immune cells, fibroblasts, lymphocytes, and other components that change the progression of tumors. Alterations in TME components largely affect genitourinary tumor metastasis and contribute to poor patient outcomes. With the deeper study of the human transcriptome, more and more non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are involved in tumor microenvironment mediated tumorigenesis, angiogenesis, invasion, metastasis and chemoresistance. Elucidating the regulatory relationship between ncRNAs and TME could help develop novel treatment strategies for genitourinary tumors, which would be highly beneficial for improving the survival prognosis of patients with tumors.
The composition of the TME is complex, and multiple ncRNAs are known to play an effect in the TME, but more studies are needed to access the specific regulatory roles. Moreover, how to regulate the aberrant expression of ncRNAs in the TME is an urgent question to be investigated. Therefore, we endeavored to discover the important regulatory roles of ncRNAs in various components of the TME and provide a necessary theoretical basis for their application in tumour diagnosis and therapy. We welcome authors to submit original research and review articles to help better understand the complex network of TME and ncRNAs interactions in a genitourinary tumor, which regulate tumor growth, metastasis, immune escape mechanisms, and drug resistance.
We also welcome pure bioinformatics research and network pharmacology research, but we need independent sample / cohort data or experimental verification. Similarly, high-quality meta analysis is also welcomed. However, case reports or letters are not accepted. The minimum requirement for group size of submitted articles is 100.
Potential topics include, but are not limited to:
• Interactions between the TME and ncRNAs lead to immune escape mechanisms and therapeutic resistance;
• Metabolic reprogramming regulated by ncRNAs in the TME;
• Discovery of novel ncRNAs that could serve as markers of tumor metastasis;
• ncRNAs involved in tumorigenesis, invasion, metastasis in TME;
• The mechanism by which the TME influences tumor metastasis;
• Development of ncRNAs based therapies
The composition of the TME is complex, and multiple ncRNAs are known to play an effect in the TME, but more studies are needed to access the specific regulatory roles. Moreover, how to regulate the aberrant expression of ncRNAs in the TME is an urgent question to be investigated. Therefore, we endeavored to discover the important regulatory roles of ncRNAs in various components of the TME and provide a necessary theoretical basis for their application in tumour diagnosis and therapy. We welcome authors to submit original research and review articles to help better understand the complex network of TME and ncRNAs interactions in a genitourinary tumor, which regulate tumor growth, metastasis, immune escape mechanisms, and drug resistance.
We also welcome pure bioinformatics research and network pharmacology research, but we need independent sample / cohort data or experimental verification. Similarly, high-quality meta analysis is also welcomed. However, case reports or letters are not accepted. The minimum requirement for group size of submitted articles is 100.
Potential topics include, but are not limited to:
• Interactions between the TME and ncRNAs lead to immune escape mechanisms and therapeutic resistance;
• Metabolic reprogramming regulated by ncRNAs in the TME;
• Discovery of novel ncRNAs that could serve as markers of tumor metastasis;
• ncRNAs involved in tumorigenesis, invasion, metastasis in TME;
• The mechanism by which the TME influences tumor metastasis;
• Development of ncRNAs based therapies
Keywords: non-coding RNAs, tumor microenvironment, genitourinary tumor
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
