About this Research Topic
General anesthetics can cause long-term cognitive and behavioral impairments in both neonatal and aging animals. An association has been found between early-life anesthesia exposure and sustained neurobehavioral deficits in young children, based on epidemiological evidence. Perioperative neurocognitive disorder (PND) is one of the most frequent postoperative complications in the elderly. Millions of patients undergo general anesthesia for surgical or diagnostic purposes annually, and there is a rising apprehension that these general anesthetics may have enduring impacts on the central nervous system, particularly in the elderly and young patients. Consequently, the maintenance of perioperative brain health is critical in decreasing postoperative neurological complications among infants, young children, and the elderly.
The present Research Topic aims to cover recent advances and discoveries related to postoperative cognitive impairment outcomes for the elderly and neurotoxicity for young children with omics-based technologies (e.g., genomics, transcriptomics, proteomics, metabolomics, and single-cell sequencing). Both pre-clinical and clinical studies with a significant neuroscience component are welcome and encouraged for submission by authors.
Our primary focus is on obtaining up-to-date information regarding the mechanistic investigation and targeted intervention research into the potential neurotoxic effects of perioperative factors on the elderly and young children. Manuscripts that concentrate on perioperative neurocognitive disorders in the form of original articles and brief research reports are eligible for submission. We also encourage authors to submit review articles, systematic review articles, and perspectives articles that are related to the subject matter.
Topics of interest include but are not limited to:
Pre-clinical studies:
- The relationship between perioperative cognitive impairment and aging brain pathologies, such as Alzheimer's disease and other forms of dementia.
- Molecular mechanism of anesthetic-induced neurotoxicity.
- Examining the effects of general anesthetics on different types of neural cells in the brain can be achieved through omics analysis approaches.
Clinical studies:
- The application of either omics technology or nanotechnology was employed in a study with the purpose of examining the biomarker of perioperative cognitive impairment in the elderly.
- Employing computational models and machine learning methodologies to predict and assess the risk of developing perioperative cognitive impairment in the elderly.
- Brain imaging studies that evaluated the potential neurotoxic effects of perioperative factors.
The present Research Topic aims to cover recent advances and discoveries related to postoperative cognitive impairment outcomes for the elderly and neurotoxicity for young children with omics-based technologies (e.g., genomics, transcriptomics, proteomics, metabolomics, and single-cell sequencing). Both pre-clinical and clinical studies with a significant neuroscience component are welcome and encouraged for submission by authors.
Our primary focus is on obtaining up-to-date information regarding the mechanistic investigation and targeted intervention research into the potential neurotoxic effects of perioperative factors on the elderly and young children. Manuscripts that concentrate on perioperative neurocognitive disorders in the form of original articles and brief research reports are eligible for submission. We also encourage authors to submit review articles, systematic review articles, and perspectives articles that are related to the subject matter.
Topics of interest include but are not limited to:
Pre-clinical studies:
- The relationship between perioperative cognitive impairment and aging brain pathologies, such as Alzheimer's disease and other forms of dementia.
- Molecular mechanism of anesthetic-induced neurotoxicity.
- Examining the effects of general anesthetics on different types of neural cells in the brain can be achieved through omics analysis approaches.
Clinical studies:
- The application of either omics technology or nanotechnology was employed in a study with the purpose of examining the biomarker of perioperative cognitive impairment in the elderly.
- Employing computational models and machine learning methodologies to predict and assess the risk of developing perioperative cognitive impairment in the elderly.
- Brain imaging studies that evaluated the potential neurotoxic effects of perioperative factors.
Keywords: anesthesia/surgery, postoperative cognitive dysfunction, postoperative delirium, neurotoxicity, omics, single-cell sequencing, nanotechnology, biomarker
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
