About this Research Topic
Programmed cell death (PCD) is a biological process where cells are deliberately destroyed, which is important for maintaining tissue homeostasis. The understanding of PCD has been a critical area of research in recent years due to its significant role in various diseases, including cancer and neurodegeneration. Emerging evidence has shown that apoptosis, necroptosis, ferroptosis, and autophagy, the primary types of PCD, are finely regulated by multiple extrinsic and intrinsic pathways. Emerging evidence has shown that these pathways are interconnected and work in a coordinated manner to execute cell death. This crosstalk can result in the switching between these pathways, suggesting that the balance between different types of PCD can be regulated by these complex interactions. Overall, the study of the crosstalk between the different types of PCD pathways and their signaling molecules is a rapidly evolving area of research that has implications for the development of therapies for various diseases.
This Research Topic is focused on the signals in programmed cell death and their crosstalk. The aim is to provide a comprehensive overview of the current knowledge regarding the regulation of signaling pathways involved in different types of programmed cell death, and how they interplay. It also aims to highlight the important molecular mechanisms that govern programmed cell death, and how their crosstalk influences the pathogenesis of different diseases. Lastly, the Research Topic aims to provide an update on emerging therapeutic strategies targeting programmed cell death and their signaling pathways.
Topics that papers are expected to cover:
• Molecular mechanisms of PCD
• Crosstalk between apoptosis, necroptosis, and autophagy
• Signaling pathways involved in programmed cell death
• Role of non-coding RNAs in programmed cell death
• The role of the inflammasome in programmed cell death
• Crosstalk between programmed cell death and immunity
• Role of programmed cell death and their crosstalk in cancer, neurodegeneration, and autoimmune disorders
• Emerging therapeutic strategies targeting programmed cell death and their signaling pathways
This Research Topic is focused on the signals in programmed cell death and their crosstalk. The aim is to provide a comprehensive overview of the current knowledge regarding the regulation of signaling pathways involved in different types of programmed cell death, and how they interplay. It also aims to highlight the important molecular mechanisms that govern programmed cell death, and how their crosstalk influences the pathogenesis of different diseases. Lastly, the Research Topic aims to provide an update on emerging therapeutic strategies targeting programmed cell death and their signaling pathways.
Topics that papers are expected to cover:
• Molecular mechanisms of PCD
• Crosstalk between apoptosis, necroptosis, and autophagy
• Signaling pathways involved in programmed cell death
• Role of non-coding RNAs in programmed cell death
• The role of the inflammasome in programmed cell death
• Crosstalk between programmed cell death and immunity
• Role of programmed cell death and their crosstalk in cancer, neurodegeneration, and autoimmune disorders
• Emerging therapeutic strategies targeting programmed cell death and their signaling pathways
Keywords: Apoptosis, Necroptosis, Autophagy, Inflammasome, Immunity, Cancer, Neurodegeneration, Autoimmune disorders
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
