The Noncoding Genome in Auditory Function and Hearing Loss

Although significant progress has been made in understanding the roles of various genes in the development and function of the auditory system, and while genetic variants in these genes have been linked to hearing loss, our knowledge of the roles played by non-coding genetic elements remains limited. These elements include enhancers, promoters, micro-RNAs, and other non-coding RNA molecules.

This research topic will focus on recent discoveries related to epigenetics and the non-coding genome in auditory function and hearing loss. The exploration of these subjects holds the potential to shed new light on the mechanisms of hearing loss and unveil novel therapeutic avenues. We aim to publish cutting-edge manuscripts that explore these subjects. The following is a non-exhaustive list of subjects to be covered in this research topic:

- Non-coding Elements in Auditory System Development and Function
- Epigenetic and Epigenomic Influences on the Development and Function of the auditory system
- Characterization of the non-coding genome in inner ears of humans and animal models
- Hearing loss caused by variants in non-coding genetic elements
- The role of non-coding elements in age-related hearing loss, and ototoxicity and noise-induced hearing loss
- Inner ear regeneration and its connection to the non-coding genome

Keywords: molecular, genetic, non coding genome, auditory function, hearing loss

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