About this Research Topic
The upper digestive tract comprises the oesophagus, stomach, duodenum, pancreas, and liver. Advanced cancer in the upper digestive tract often results in metastasis, including lymphatic and hematogenous metastasis, which severely impacts patient survival and treatment outcomes. Several factors must be taken into account when determining effective treatment strategies, such as how far the cancer has progressed, the location of the metastases, and the unique characteristics or types of cancer cells that present at the site of metastasis in the upper digestive tract. Therefore, gaining a better understanding of metastasis mechanisms is crucial to improving the success rate of treatment and metastasis prevention.
This Research Topic aims to identify new markers and mechanisms of cancer metastasis in the upper digestive tract, along with a detailed discussion of diagnosis and treatment after metastasis has occurred. Authors are encouraged to submit Original Research articles, Brief Research Reports, and Reviews on the following (but not limited to) subtopics:
• Comprehensive exploration of biochemical, molecular biological, genetic, epigenetic, and metabolomic alterations and pathophysiology underlying the progression of upper digestive tract tumor metastasis;
• Examining the role of mechanisms such as copper-induced death, ferroptosis, and mitophagy that play in the progression of upper digestive tract tumor metastasis;
• Discussion of different treatment options, including surgeries, radiochemotherapy and immunotherapy for upper digestive tract tumor metastasis;
• Identification and evaluation of novel prevention mechanisms and potential therapeutic targets in upper digestive tract tumor metastasis.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
This Research Topic aims to identify new markers and mechanisms of cancer metastasis in the upper digestive tract, along with a detailed discussion of diagnosis and treatment after metastasis has occurred. Authors are encouraged to submit Original Research articles, Brief Research Reports, and Reviews on the following (but not limited to) subtopics:
• Comprehensive exploration of biochemical, molecular biological, genetic, epigenetic, and metabolomic alterations and pathophysiology underlying the progression of upper digestive tract tumor metastasis;
• Examining the role of mechanisms such as copper-induced death, ferroptosis, and mitophagy that play in the progression of upper digestive tract tumor metastasis;
• Discussion of different treatment options, including surgeries, radiochemotherapy and immunotherapy for upper digestive tract tumor metastasis;
• Identification and evaluation of novel prevention mechanisms and potential therapeutic targets in upper digestive tract tumor metastasis.
Please note: studies consisting solely of bioinformatic investigation of publicly available genomic/transcriptomic/proteomic data do not fall within the scope of the section unless they are expanded and provide significant biological or mechanistic insight into the process being studied and will not be accepted as part of this Research Topic.
Keywords: tumor metastasis, upper digestive tract, pathways, radiochemotherapy, immunotherapy, copper death, ferroptosis, mitophagy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
