About this Research Topic
This Research Topic is part of the 15-Year Anniversary of Frontiers in Cellular Neuroscience Research Topic series, which has been organized in collaboration with the Neuroscience portfolio at Frontiers to celebrate the 15-Year Anniversary of the journal. This series aims to highlight some of the most impactful research areas in this field and provide discussion around the latest advances in RNA dysregulation in neurodegenerative disease as well as new research on this important topic.
By following its mission to freely disseminate high-quality research with a worldwide reach, Frontiers in Cellular Neuroscience will continue to play a key role in accelerating the progress of Cellular Neuropathology research and making Open Science a global reality.
This Research Topic article collection focuses on elucidating the role of RNA dysregulation in neurodegenerative diseases.
RNA dysregulation is emerging as a critical mechanism underlying the pathogenesis of neurodegenerative diseases. Abnormalities in RNA metabolism, including transcription, splicing, polyadenylation, axonal transport, translation, and degradation, have been implicated in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. Understanding the molecular basis of RNA dysregulation and its impact on neuronal function and survival is essential for developing effective treatments for these devastating conditions.
This Research Topic aims to highlight recent advances in the field of RNA dysregulation in neurodegenerative diseases by bringing together original research articles, reviews, mini-reviews, and perspectives. The topics of interest include but are not limited to:
- Functional and mechanistic studies of disease-associated RNA-binding proteins, such as TDP-43, FUS, hnRNPA1, and TIA1
- Analysis of RNA processing defects, such as alternative splicing, exon skipping, and RNA editing, in various neurodegenerative diseases
- Investigation of non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, in disease pathogenesis and as potential therapeutic targets
- Identification of RNA targets that contribute to neurodegeneration and neuronal cell death.
- Development of RNA-based therapies, including gene therapy, RNA interference, antisense oligonucleotides, and small molecules, for treating neurodegenerative diseases.
We welcome submissions from researchers working on any aspect of RNA dysregulation in neurodegenerative diseases and encourage interdisciplinary approaches that bridge the fields of genetics, genomics, neuroscience, and biochemistry. Our goal is to foster a comprehensive understanding of the role of RNA dysregulation in neurodegenerative diseases and to facilitate the development of novel diagnostics and therapeutics for these devastating disorders.
By following its mission to freely disseminate high-quality research with a worldwide reach, Frontiers in Cellular Neuroscience will continue to play a key role in accelerating the progress of Cellular Neuropathology research and making Open Science a global reality.
This Research Topic article collection focuses on elucidating the role of RNA dysregulation in neurodegenerative diseases.
RNA dysregulation is emerging as a critical mechanism underlying the pathogenesis of neurodegenerative diseases. Abnormalities in RNA metabolism, including transcription, splicing, polyadenylation, axonal transport, translation, and degradation, have been implicated in various neurological disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, and frontotemporal dementia. Understanding the molecular basis of RNA dysregulation and its impact on neuronal function and survival is essential for developing effective treatments for these devastating conditions.
This Research Topic aims to highlight recent advances in the field of RNA dysregulation in neurodegenerative diseases by bringing together original research articles, reviews, mini-reviews, and perspectives. The topics of interest include but are not limited to:
- Functional and mechanistic studies of disease-associated RNA-binding proteins, such as TDP-43, FUS, hnRNPA1, and TIA1
- Analysis of RNA processing defects, such as alternative splicing, exon skipping, and RNA editing, in various neurodegenerative diseases
- Investigation of non-coding RNAs, including microRNAs, long non-coding RNAs, and circular RNAs, in disease pathogenesis and as potential therapeutic targets
- Identification of RNA targets that contribute to neurodegeneration and neuronal cell death.
- Development of RNA-based therapies, including gene therapy, RNA interference, antisense oligonucleotides, and small molecules, for treating neurodegenerative diseases.
We welcome submissions from researchers working on any aspect of RNA dysregulation in neurodegenerative diseases and encourage interdisciplinary approaches that bridge the fields of genetics, genomics, neuroscience, and biochemistry. Our goal is to foster a comprehensive understanding of the role of RNA dysregulation in neurodegenerative diseases and to facilitate the development of novel diagnostics and therapeutics for these devastating disorders.
Keywords: RNA, neurodegeneration, ALS, FTD, Alzheimer's, splicing, non-coding RNA, microRNA, RNA binding protein
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
