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Manuscript Submission Deadline 31 December 2023

With progress in both science and technological capabilities over the last several decades and the subsequent significant decline in mortality following pediatric intensive care admission, the focus has turned to survival with good neurological outcomes and optimization of quality of life after discharge. ...

With progress in both science and technological capabilities over the last several decades and the subsequent significant decline in mortality following pediatric intensive care admission, the focus has turned to survival with good neurological outcomes and optimization of quality of life after discharge. With the change in focus, there is an increased understanding that many critically ill children are at risk of decreased neurofunctional status, brain injury, and neurodevelopmental difficulties affecting later life. A recognition of neurodevelopmental impairment and brain injury secondary to the hospital course in both pediatric cardiac and non-cardiac intensive care units has led to improved assessment, monitoring, and interventions to optimize protection of the brain.

This Research Topic seeks to provide an update on state-of-the-art practices for the prevention, early detection, intervention (including inpatient developmental care), and short- and long-term follow-up for pediatric neurodevelopmental impairment after pediatric intensive care admission. Contributions will focus on recent advancements in identifying patients at risk, both clinical and physiological assessment tools, implementation of prevention techniques, and long-term outcomes and follow-up. We will also provide updates on the pathophysiology of neurodevelopmental risk factors and mechanisms of brain injury and their influence on long-term patient outcomes, along with a review of psychological distress in parents and the impact of parent coping on childhood outcomes.

This Research Topic will focus on, but is not limited to:

1. Epidemiology of neurodevelopmental impairment after PICU admission.

2. Pathophysiology of brain injury.

3. Pediatric delirium and its influence on outcomes.

4. Inpatient interventions to optimize neurodevelopmental outcomes

5. New standardized clinical assessment tools for age-appropriate, clinical evaluation of neurofunctional status.

6. Current and futuristic non-invasive and invasive monitoring of the brain.

7. Childhood 'post-intensive care syndrome’ and approaches for appropriate neurodevelopmental follow-up.

8. Developmental care interventions such as NIDCAP to support long-term outcomes.

9. Parent stress and resilience in interaction with child neurodevelopment.

Keywords: neurodevelopment, pediatric intensive care, brain injury, post intensive care syndrome, congenital heart disease, brain monitoring, delirium


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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