About this Research Topic
Sphingolipids are a class of essential biomolecules widely present in cell membranes, involved in crucial physiological processes such as cell signaling, proliferation, and apoptosis. Dysregulated sphingolipid metabolism plays a significant role in cancer development and treatment. Increasing evidence indicates the close association between aberrant sphingolipid metabolism and the development of various cancers as well as treatment resistance. Intervention strategies targeting sphingolipid metabolism have shown tremendous potential in cancer chemotherapy, radiotherapy, and immunotherapy. Therefore, sphingolipid metabolism in cancer treatment has become a highly focused research area.
This Research Topic aims to explore how the modulation of sphingolipid metabolism improves the efficacy of chemotherapy, radiotherapy, and immunotherapy in cancer treatment, providing novel insights and approaches for cancer therapy. Through the collection of high-quality original research and reviews, our goal is to advance the understanding of sphingolipid metabolism field, promote the development of novel tumor treatment strategies, and provide more effective therapeutic options for cancer patients. We welcome submissions covering but are not limited to the following:
1) Key roles of sphingolipid metabolism in cancer development: introducing the involvement of sphingolipid metabolism in tumor progression, proliferation, metastasis, as well as its significance in patient prognosis, and analyzing its potential molecular mechanisms.
2) Relationship between sphingolipid metabolism and chemotherapy: exploration of the interactions between sphingolipid metabolism and chemotherapy drugs, as well as strategies to modulate sphingolipid metabolism to enhance chemotherapy efficacy and reduce drug resistance.
3) Impact of sphingolipid metabolism on radiotherapy: investigation of sphingolipid metabolism in radiotherapy sensitivity and resistance, and exploring strategies to modulate sphingolipid metabolism for enhanced radiotherapy outcomes.
4) Association between sphingolipid metabolism and immunotherapy: discussion on the involvement of sphingolipid metabolism in immunotherapy, including its effects on immune checkpoint inhibitors' response and tumor immune evasion, and exploring the potential of regulating sphingolipid metabolism to improve immunotherapy efficacy.
5) Therapeutic strategies related to sphingolipid metabolism: introduction of novel therapeutic approaches targeting sphingolipid metabolism, including sphingolipid synthesis inhibition, modulation of sphingolipid levels, and targeting sphingolipid metabolic enzymes, to enhance cancer treatment outcomes.
6) Advances in technologies and tools utilized in sphingolipid metabolism research, such as metabolomics, mass spectrometry analysis, gene editing, and cellular imaging, along with their applications and challenges in research.
7) Clinical application prospects: discussion on the potential applications and challenges of sphingolipid metabolism intervention strategies in the clinical setting, including treatment plan optimization, personalized therapy, and drug development.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
This Research Topic aims to explore how the modulation of sphingolipid metabolism improves the efficacy of chemotherapy, radiotherapy, and immunotherapy in cancer treatment, providing novel insights and approaches for cancer therapy. Through the collection of high-quality original research and reviews, our goal is to advance the understanding of sphingolipid metabolism field, promote the development of novel tumor treatment strategies, and provide more effective therapeutic options for cancer patients. We welcome submissions covering but are not limited to the following:
1) Key roles of sphingolipid metabolism in cancer development: introducing the involvement of sphingolipid metabolism in tumor progression, proliferation, metastasis, as well as its significance in patient prognosis, and analyzing its potential molecular mechanisms.
2) Relationship between sphingolipid metabolism and chemotherapy: exploration of the interactions between sphingolipid metabolism and chemotherapy drugs, as well as strategies to modulate sphingolipid metabolism to enhance chemotherapy efficacy and reduce drug resistance.
3) Impact of sphingolipid metabolism on radiotherapy: investigation of sphingolipid metabolism in radiotherapy sensitivity and resistance, and exploring strategies to modulate sphingolipid metabolism for enhanced radiotherapy outcomes.
4) Association between sphingolipid metabolism and immunotherapy: discussion on the involvement of sphingolipid metabolism in immunotherapy, including its effects on immune checkpoint inhibitors' response and tumor immune evasion, and exploring the potential of regulating sphingolipid metabolism to improve immunotherapy efficacy.
5) Therapeutic strategies related to sphingolipid metabolism: introduction of novel therapeutic approaches targeting sphingolipid metabolism, including sphingolipid synthesis inhibition, modulation of sphingolipid levels, and targeting sphingolipid metabolic enzymes, to enhance cancer treatment outcomes.
6) Advances in technologies and tools utilized in sphingolipid metabolism research, such as metabolomics, mass spectrometry analysis, gene editing, and cellular imaging, along with their applications and challenges in research.
7) Clinical application prospects: discussion on the potential applications and challenges of sphingolipid metabolism intervention strategies in the clinical setting, including treatment plan optimization, personalized therapy, and drug development.
Please note: manuscripts consisting solely of bioinformatics or computational analysis of public genomic or transcriptomic databases which are not accompanied by validation (independent cohort or biological validation in vitro or in vivo) are out of scope for this section and will not be accepted as part of this Research Topic.
Keywords: sphingolipid, cancer, chemotherapy, immunotherapy, radiotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
