Screen the novel therapeutic targets and construct nano-delivery system to enhance the immunotherapy sensitivity of microsatellite stability cancer

Cancer immunotherapies have been considered one of the most promising tumor treatment methods in the 21st century. It can activate the host's anti-tumor immunity, promote tumor reduction, and ultimately result in increasing overall patients' survival rate. Despite the fact that immunotherapy has shown astonishing results in many cancers, the beneficiaries are still very limited. Since A vast majority of cancer cases are microsatellite stable (MSS) and respond poorly to anti-PD-1/PD-L1 immunotherapies. There is an urgent need to find new targets for cancer immunotherapy from the aspects of Tumor microenvironment remodeling, neoantigen generation, immunogenicity enhancement, etc. Ultimately, enhancing the sensitivity of cancer immunotherapy in MSS cancer, especially colorectal cancer. Besides, some immune-related diseases may progress to tumors, and immune factors are closely related to disease activity and prognosis. It is necessary to explore relevant immune indicators to predict disease progression to guide clinical practice and provide theoretical basis for new therapeutic targets. Much more interesting, a series of new tumor treatment methods, such as photodynamic therapy and sonodynamic therapy, have been proven to effectively enhance the sensitivity of tumor immunotherapy. At the same time, photosensitizers and sonosensitizers can also play important roles in tumor imaging and target delivery. Therefore, exploring efficient photosensitizers and sonosensitizer as delivery carriers is also an important direction for future research in immunotherapy.

This research topic aims to publish high-quality original research, reviews, perspective articles, and unique case reports on novel personalized therapeutic targets for immunotherapy and investigate the detailed mechanisms, and construct new intelligent nano-photosensitizers and sonosensitizer for co-delivery of targets, especially in MSS cancer and immune-related diseases that may progress to tumors.

- Mechanisms of antigen presentation and manufacture of dendritic cells in the tumor microenvironment (TME) of MSS cancer
- Systematic screening and validation of potential targets to enhance the sensitivity of cancer immunotherapy in MSS cancer – e.g., targets that increase chromosomal instability, explore the immune indicators related to disease activity and prognosis to guide clinical practice
- Different combination therapeutic strategies based on personalized cancer immunotherapy targets – e.g., the combination of photodynamic therapy and personalized cancer immunotherapy targets, the combination of sonodynamic therapy and personalized cancer immunotherapy targets, the combination of stem cells and personalized cancer immunotherapy targets, the combination of ferroptosis inducer and personalized cancer immunotherapy targets, etc.

Keywords: microsatellite stability cancer

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