Fiber-based Biomaterials for Tissue Engineering and Regenerative Medicine

Tissue engineering and regenerative medicine hold tremendous promise for addressing the challenges associated with tissue damage, organ failure, and degenerative diseases. One of the key components in this field is the development of biomaterials that can mimic the extracellular matrix and provide structural support, promote cell adhesion, proliferation, and differentiation. Fiber-based biomaterials have emerged as a versatile and effective platform for tissue regeneration applications due to their unique characteristics, including high surface area, tunable mechanical properties, and the ability to mimic native tissue architecture. These materials can be fabricated from natural, synthetic, or hybrid polymers and offer a wide range of possibilities for designing and engineering functional constructs.

Despite significant progress in the field of fiber-based biomaterials for tissue engineering and regenerative medicine, there are still challenges that need to be addressed. This call for paper submission aims to highlight the latest advances and breakthroughs in this area and foster discussions on strategies to overcome existing limitations. Recent advances include the development of novel fabrication techniques, such as solution spinning, melt spinning, and 3D bioprinting, which enables the precise control of fiber morphology, alignment, and functionalization. Additionally, surface modification techniques, such as chemical grafting, bioactive molecule incorporation, and coating, have been explored to enhance cell-material interactions, promote tissue regeneration, and enable controlled drug delivery.

We invite researchers and experts in the field to contribute original research articles, reviews, and perspectives that address various themes related to fiber-based biomaterials for tissue engineering and regenerative medicine. Specific topics of interest include but are not limited to:

• Novel fabrication techniques for fiber-based biomaterials
• Surface modification strategies to enhance biocompatibility and bioactivity
• Characterization techniques for fiber-based biomaterials
• Scaffold design and engineering for specific tissue applications
• Cell-material interactions and biocompatibility studies
• Controlled drug release and therapeutic applications
• Preclinical and clinical evaluations of fiber-based biomaterials
• Emerging trends and future perspectives in the field

We encourage contributions that present interdisciplinary research, showcase innovative approaches, and provide insights into the translational potential of fiber-based biomaterials. Manuscripts can range from original research articles reporting experimental findings to comprehensive reviews, methodological advancements, and perspective pieces that highlight future directions.

Keywords: Biomimetic scaffolds, Fiber spinning, Cell-material interactions, Tissue regeneration, Controlled drug delivery

Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.