Single Cell RNA Expression in Pancreatic Cancer

It has been repeatedly stated and observed that pancreatic cancer is a very heterogeneous disease. Only recently with the advances in single cell technologies, have we begun to explore what modifications we see in tumor cell gene expression and tumor microenvironment gene expression. Also, it will be essential to elucidate the functional impacts of gene expression changes in the context of disease development, progression, and response to treatment both within and between cell types.

We look for this collection to represent what is currently known in pancreatic cancer single cell gene expression and significant advances in the field of single cell technology applied in pancreatic cancer studies.

The aim of this Research Topic area is to highlight what is currently known about the single cell RNA expression landscape in pancreatic cancer. Both systematic reviews on RNA expression and original research will be welcomed in this collection. Specific topics that are of interest included, but are not limited to:

• single cell RNA-seq studies in pancreatic cancer

• spatial transcriptomic studies in pancreatic cancer

• comparisons between gene expression in tumor microenvironment and cancer cells

• scATAC-seq in pancreatic cancer

• single cell gene expression changes throughout disease progression

• single cell gene expression changes in response to treatment

Keywords: single cell, RNA, pancreatic cancer

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