About this Research Topic
Why some euploid embryos fail to implant and give rise to a successful pregnancy, while other euploid embryos do not, remains unanswered. Yet the answer may reveal itself through study of other molecular metrics associated with embryos that yield successful pregnancies. In order to improve one’s prediction of embryo competence, we have to identify metrics inherent in the preimplantation embryo beyond ploidy status.
Recent literature suggests that pre-implantation genetic testing for aneuploidy (PGT-A) may not substantially improve pregnancy rates in younger women, and exactly what genetic information PGT-A is providing about the whole embryo remains unclear. Therefore, an additional molecular metric to assess preimplantation embryos could be used in addition to PGT-A to better predict embryo competence.
This Research Topic welcomes submissions covering, but not limited to, the following themes:
• Description of novel embryo viability metrics and markers collected using non-invasive or minimally-invasive techniques
• Embryo viability comparison from those harboring whole chromosome aneuploidies versus partial chromosome aneuploidies
• Use of PGT-A in combination with another novel embryo metric to assess IVF-embryo competence
• Analysis of molecular components found in spent media throughout blastocyst culture.
Recent literature suggests that pre-implantation genetic testing for aneuploidy (PGT-A) may not substantially improve pregnancy rates in younger women, and exactly what genetic information PGT-A is providing about the whole embryo remains unclear. Therefore, an additional molecular metric to assess preimplantation embryos could be used in addition to PGT-A to better predict embryo competence.
This Research Topic welcomes submissions covering, but not limited to, the following themes:
• Description of novel embryo viability metrics and markers collected using non-invasive or minimally-invasive techniques
• Embryo viability comparison from those harboring whole chromosome aneuploidies versus partial chromosome aneuploidies
• Use of PGT-A in combination with another novel embryo metric to assess IVF-embryo competence
• Analysis of molecular components found in spent media throughout blastocyst culture.
Keywords: Embryo competence, IVF, PGT-A, pre-implantation embryo, blastocyst, ploidy status
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
