Research Topic

Physical Activity and Diet in Atherosclerosis: Systemic, Vascular and Brain Outcomes

About this Research Topic

Atherosclerosis is a chronic inflammatory disease that is characterized by plaque buildup within the vessel walls. An initial step in the pathogenesis of this disease involves the oxidation of lipids, which not only produces inflammation, but more oxidative stress as well. Although it is primary a vessel wall disease, atherosclerosis is also known to causes stroke, the leading cause of disabilities worldwide. This pathology is due to a lack of circulating cholesterol management and it could lead to more pernicious outcomes such as the disorganization of cerebrovascular units that, when combined with systemic and local inflammation, can result in serious repercussions in the brain.
Interestingly, numerous studies indicate that both physical exercise and diet are important modulators of oxidative stress and inflammation which in turn could play a role in the peripheral and central outcomes of atherosclerosis.
The present Research Topic aims to focus on the effects of the exercise training and/or diet in particular in regards to its content in cholesterol, omega-3 and -6, and its amount (restricted diet vs. overfeeding) on peripheral and central outcomes of atherosclerosis. Understanding the mechanisms underlying the systemic, vascular and brain pathophysiological alterations observed in patient and animal models of atherosclerosis may be promising for the reduction in cardio-and cerebrovascular morbidity in this population.


Keywords: Exercise, diet, atherosclerosis, cholesterol, peripheral and central effects


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

Atherosclerosis is a chronic inflammatory disease that is characterized by plaque buildup within the vessel walls. An initial step in the pathogenesis of this disease involves the oxidation of lipids, which not only produces inflammation, but more oxidative stress as well. Although it is primary a vessel wall disease, atherosclerosis is also known to causes stroke, the leading cause of disabilities worldwide. This pathology is due to a lack of circulating cholesterol management and it could lead to more pernicious outcomes such as the disorganization of cerebrovascular units that, when combined with systemic and local inflammation, can result in serious repercussions in the brain.
Interestingly, numerous studies indicate that both physical exercise and diet are important modulators of oxidative stress and inflammation which in turn could play a role in the peripheral and central outcomes of atherosclerosis.
The present Research Topic aims to focus on the effects of the exercise training and/or diet in particular in regards to its content in cholesterol, omega-3 and -6, and its amount (restricted diet vs. overfeeding) on peripheral and central outcomes of atherosclerosis. Understanding the mechanisms underlying the systemic, vascular and brain pathophysiological alterations observed in patient and animal models of atherosclerosis may be promising for the reduction in cardio-and cerebrovascular morbidity in this population.


Keywords: Exercise, diet, atherosclerosis, cholesterol, peripheral and central effects


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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Submission Deadlines

01 December 2017 Manuscript
31 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

01 December 2017 Manuscript
31 January 2018 Manuscript Extension

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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