About this Research Topic
Atherosclerosis is a chronic inflammatory disease that is characterized by plaque buildup within the vessel walls. An initial step in the pathogenesis of this disease involves the oxidation of lipids, which not only produces inflammation, but more oxidative stress as well. Although it is primary a vessel wall disease, atherosclerosis is also known to causes stroke, the leading cause of disabilities worldwide. This pathology is due to a lack of circulating cholesterol management and it could lead to more pernicious outcomes such as the disorganization of cerebrovascular units that, when combined with systemic and local inflammation, can result in serious repercussions in the brain.
Interestingly, numerous studies indicate that both physical exercise and diet are important modulators of oxidative stress and inflammation which in turn could play a role in the peripheral and central outcomes of atherosclerosis.
The present Research Topic aims to focus on the effects of the exercise training and/or diet in particular in regards to its content in cholesterol, omega-3 and -6, and its amount (restricted diet vs. overfeeding) on peripheral and central outcomes of atherosclerosis. Understanding the mechanisms underlying the systemic, vascular and brain pathophysiological alterations observed in patient and animal models of atherosclerosis may be promising for the reduction in cardio-and cerebrovascular morbidity in this population.
Keywords: Exercise, diet, atherosclerosis, cholesterol, peripheral and central effects
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