About this Research Topic
Since Goldblatt’s seminal experiment in 1934 (J. Exp. Med. 59: 347, 1934), renal hypertension has increasingly been recognized as an important cause of clinically atypical hypertension and chronic kidney disease, the latter by virtue of renal ischemia. Followed later by important work, the scientific community recognized that the kidney not only increases blood pressure by renal artery occlusion and is victim to hypertension-related injury, but also contributes to arterial blood pressure by an array of multiple systemic or local mechanisms, which all contribute to renal hypertension.
Our goal for this Frontiers Research Topic is to highlight the significant reach of the kidney in blood pressure regulation, from renovascular hypertension due to renal artery-occlusive disease to renoparenchymal hypertension and genes involved in renal salt homeostasis. In doing so, we explicitly place findings that can be taken advantage of in creating new therapies for cardiovascular diseases that continue to challenge our community. These include resistant hypertension, renal artery interventions, medical genetics, diabetes and salt consumption in health and disease to name a few.
Keywords: Renovascular, renoparenchymal, genetics, salt conservation, denervation
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