Research Topic

Developing an Artificial Kidney: From Understanding Cellular Differentiation to an Implantable Artificial Organ

About this Research Topic

The kidney has vital functions in maintaining water balance, acid-base homeostasis and in eliminating waste. Chronic kidney disease (CKD) is a global public health priority according to the Global Burden of Disease study, because the increasing number of deaths worldwide. The magnitude of the CKD epidemic is comparable to that of diabetes mellitus. Patients with CKD frequently progress to end-stage kidney disease (ESKD), which is associated with major disability, poor quality of life, decreased life expectancy, and a tremendous social and financial burden. To survive, ESKD patients have to receive renal replacement therapy (RRT) in the form of kidney transplantation or dialysis. The annual incidence rate of patients starting RRT ranges from 150 to 400 people per million population (pmp) in the Western world and 50 pmp or even less in poor countries where access to health care is limited. The limited access to RRT for many CKD patients worldwide and the numerous complications associated with RRT drive the need for novel approaches such as an artificial kidney. Kidney function is critically dependent on its three dimensional (3D) architecture, which necessitates the development of innovative tissue model systems. Thus, the shift towards using 3D tissue models as high fidelity tools to facilitate the transition from basic cellular research to clinical applications such as artificial organs is logical.

This series will focus on the principles and recent progress in the field of cell differentiation, tissue engineering, nanotechnology and 3D scaffolds, all of which are crucial steps in developing an artificial kidney.


Keywords: artificial kidney, kidney, cell differentiation, tissue engineering


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

The kidney has vital functions in maintaining water balance, acid-base homeostasis and in eliminating waste. Chronic kidney disease (CKD) is a global public health priority according to the Global Burden of Disease study, because the increasing number of deaths worldwide. The magnitude of the CKD epidemic is comparable to that of diabetes mellitus. Patients with CKD frequently progress to end-stage kidney disease (ESKD), which is associated with major disability, poor quality of life, decreased life expectancy, and a tremendous social and financial burden. To survive, ESKD patients have to receive renal replacement therapy (RRT) in the form of kidney transplantation or dialysis. The annual incidence rate of patients starting RRT ranges from 150 to 400 people per million population (pmp) in the Western world and 50 pmp or even less in poor countries where access to health care is limited. The limited access to RRT for many CKD patients worldwide and the numerous complications associated with RRT drive the need for novel approaches such as an artificial kidney. Kidney function is critically dependent on its three dimensional (3D) architecture, which necessitates the development of innovative tissue model systems. Thus, the shift towards using 3D tissue models as high fidelity tools to facilitate the transition from basic cellular research to clinical applications such as artificial organs is logical.

This series will focus on the principles and recent progress in the field of cell differentiation, tissue engineering, nanotechnology and 3D scaffolds, all of which are crucial steps in developing an artificial kidney.


Keywords: artificial kidney, kidney, cell differentiation, tissue engineering


Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.

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28 February 2018 Manuscript

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Manuscripts can be submitted to this Research Topic via the following journals:

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Topic Editors

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Submission Deadlines

28 February 2018 Manuscript

Participating Journals

Manuscripts can be submitted to this Research Topic via the following journals:

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