About this Research Topic
With the growing appreciation of the impact of the TME in cancer development, progression, and therapy resistance, investigations into the role of TME parameters is warranted. Traditional 2D culture platforms fail to recapitulate the complex TME cues, thus limiting the insights gained from these studies. Thus, there is a need for advanced bioengineered platforms that can enable robust interrogation of TME control of tumor evolution and spread. Exciting new reports are showing progress in modeling the TME with co-culture platforms that tease out cell-cell interactions, tunable hydrogel systems equipped with composition and stiffness control that enable matrix-cell interactions, and lab-on-a-chip devices that recapitulate several TME parameters simultaneously. Advances in these platforms will allow for new discoveries that can identify novel pharmacological targets, unravel mechanistic insights, and provide accurate high-throughput drug screening systems to improve cancer therapeutics and outcomes.
This research topic aims at collecting novel and creative works in TME modelling with a specific focus on advancing the tools available to recapitulate TME cues in vitro. These tools should consider TME factors such as matrix composition and stiffness, cell-cell interactions, oxygenation, tumor vasculature, and immune modulation. These efforts may include biomaterial innovations, high-throughput screening platforms, and basic science works that dissect TME regulation on therapy resistance, immune modulation, phenotype transition, and invasion.
• Innovative bio-printing strategies
• Novel 3D microfabrication approaches
• Tunable hydrogel systems
• Immuno-modulatory materials
• Co-culture platforms
• Microfluidic devices
• Stimuli-sensitive biomaterials
Keywords: Biomaterials, Microfabrication, Tumor Microenvironment, Hydrogels, 3D printing, High-throughput
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